Betty Soliven

Research Summary
Dr. Soliven is the Associate Chair for Faculty Affairs in the Department of Neurology. She is the Director of the EMG Laboratory and Neuromuscular Program and sees mostly patients with myasthenia, myopathy (myositis, dystrophies), amyotrophic lateral sclerosis, autoimmune and inherited neuropathies. She is involved in neuromuscular clinical trials and studies. Her laboratory research currently focuses on glial biology and immune mechanisms pertinent to autoimmune neuropathies and myasthenia gravis (MG). She chairs the Medical Advisory Board of Conquer MG, and has served as a reviewer for multiple journals, NIH NINDS study sections, and grant review committees of other funding agencies.
  • University of Chicago, Chicago, IL , Neurology Residency 06/1985
  • Columbia University Medical Center, NY, NY, EMG-Neuromuscular fellowship 06/1986
  • University of Chicago, Chicago, IL, Research fellowship in Glial Physiology 06/1989
Biosciences Graduate Program Association
  1. Dresser L, Wlodarski R, Rezania K, Soliven B. Myasthenia Gravis: Epidemiology, Pathophysiology and Clinical Manifestations. J Clin Med. 2021 May 21; 10(11). View in: PubMed

  2. Sheikh S, Alvi U, Soliven B, Rezania K. Drugs That Induce or Cause Deterioration of Myasthenia Gravis: An Update. J Clin Med. 2021 Apr 06; 10(7). View in: PubMed

  3. Howlett-Prieto Q, Langer C, Rezania K, Soliven B. Modulation of immune responses by bile acid receptor agonists in myasthenia gravis. J Neuroimmunol. 2020 12 15; 349:577397. View in: PubMed

  4. Yuen C, Soliven B, Rezania K. ATM mutation in a patient with thymoma-associated myasthenia gravis. Muscle Nerve. 2020 08; 62(2):E50-E52. View in: PubMed

  5. Yuen C, Fleming G, Meyers M, Soliven B, Rezania K. Myasthenia gravis induced by avelumab. Immunotherapy. 2019 10; 11(14):1181-1185. View in: PubMed

  6. Yuen C, Kamson D, Soliven B, Kramer C, Goldenberg F, Rezania K. Severe Relapse of Vaccine-Induced Guillain-Barré Syndrome After Treatment With Nivolumab. J Clin Neuromuscul Dis. 2019 Jun; 20(4):194-199. View in: PubMed

  7. Yuen C, Reid P, Zhang Z, Soliven B, Luke JJ, Rezania K. Facial Palsy Induced by Checkpoint Blockade: A Single Center Retrospective Study. J Immunother. 2019 04; 42(3):94-96. View in: PubMed

  8. Clayton BL, Huang A, Dukala D, Soliven B, Popko B. Neonatal Hypoxia Results in Peripheral Nerve Abnormalities. Am J Pathol. 2017 Feb; 187(2):245-251. View in: PubMed

  9. Sih M, Soliven B, Mathenia N, Jacobsen J, Rezania K. Head-drop: A frequent feature of late-onset myasthenia gravis. Muscle Nerve. 2017 09; 56(3):441-444. View in: PubMed

  10. Kak M, Issa NP, Roos RP, Sweitzer BJ, Gottlieb O, Guralnick A, White SR, Semrad CE, Soliven B, Baroody J, Rezania K. Gastrostomy tube placement is safe in advanced amyotrophic lateral sclerosis. Neurol Res. 2017 Jan; 39(1):16-22. View in: PubMed

  11. Issa NP, Frank S, Roos RP, Soliven B, Towle VL, Rezania K. Intermuscular coherence in amyotrophic lateral sclerosis: A preliminary assessment. Muscle Nerve. 2017 06; 55(6):862-868. View in: PubMed

  12. Sheng JR, Rezania K, Soliven B. Impaired regulatory B cells in myasthenia gravis. J Neuroimmunol. 2016 08 15; 297:38-45. View in: PubMed

  13. Elbaz B, Traka M, Kunjamma RB, Dukala D, Brosius Lutz A, Anton ES, Barres BA, Soliven B, Popko B. Adenomatous polyposis coli regulates radial axonal sorting and myelination in the PNS. Development. 2016 07 01; 143(13):2356-66. View in: PubMed

  14. Quan S, Sheng JR, Abraham PM, Soliven B. Regulatory T and B lymphocytes in a spontaneous autoimmune polyneuropathy. Clin Exp Immunol. 2016 Apr; 184(1):50-61. View in: PubMed

  15. Dukala DE, Soliven B. S1P1 deletion in oligodendroglial lineage cells: Effect on differentiation and myelination. Glia. 2016 Apr; 64(4):570-82. View in: PubMed

  16. Sheng JR, Quan S, Soliven B. IL-10 derived from CD1dhiCD5? B cells regulates experimental autoimmune myasthenia gravis. J Neuroimmunol. 2015 Dec 15; 289:130-8. View in: PubMed

  17. Quan S, Kim HJ, Dukala D, Sheng JR, Soliven B. Impaired dendritic cell function in a spontaneous autoimmune polyneuropathy. J Immunol. 2015 May 01; 194(9):4175-84. View in: PubMed

  18. Sheng JR, Quan S, Soliven B. CD1d(hi)CD5+ B cells expanded by GM-CSF in vivo suppress experimental autoimmune myasthenia gravis. J Immunol. 2014 Sep 15; 193(6):2669-77. View in: PubMed

  19. Soliven B. Animal models of autoimmune neuropathy. ILAR J. 2014; 54(3):282-90. View in: PubMed

  20. Abraham PM, Quan SH, Dukala D, Soliven B. CD19 as a therapeutic target in a spontaneous autoimmune polyneuropathy. Clin Exp Immunol. 2014 Feb; 175(2):181-91. View in: PubMed

  21. Soliven B. Autoimmune neuropathies: insights from animal models. J Peripher Nerv Syst. 2012 May; 17 Suppl 2:28-33. View in: PubMed

  22. Rezania K, Soliven B, Baron J, Lin H, Penumalli V, van Besien K. Myasthenia gravis, an autoimmune manifestation of lymphoma and lymphoproliferative disorders: case reports and review of literature. Leuk Lymphoma. 2012 Mar; 53(3):371-80. View in: PubMed

  23. Soliven B. Immune mechanisms in spontaneously occurring CIDP in NOD mice. J Peripher Nerv Syst. 2011 Jun; 16 Suppl 1:56-9. View in: PubMed

  24. Soliven B, Miron V, Chun J. The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators. Neurology. 2011 Feb 22; 76(8 Suppl 3):S9-14. View in: PubMed

  25. Rezania K, Soliven B, Rezai KA, Roos RP. Impaired glucose tolerance and metabolic syndrome in idiopathic polyneuropathy: the role of pain and depression. Med Hypotheses. 2011 Apr; 76(4):538-42. View in: PubMed

  26. Kim HJ, Miron VE, Dukala D, Proia RL, Ludwin SK, Traka M, Antel JP, Soliven B. Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model. FASEB J. 2011 May; 25(5):1509-18. View in: PubMed

  27. Traka M, Arasi K, Avila RL, Podojil JR, Christakos A, Miller SD, Soliven B, Popko B. A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination. Brain. 2010 Oct; 133(10):3017-29. View in: PubMed

  28. Miron VE, Ludwin SK, Darlington PJ, Jarjour AA, Soliven B, Kennedy TE, Antel JP. Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices. Am J Pathol. 2010 Jun; 176(6):2682-94. View in: PubMed

  29. Maselli RA, Arredondo J, Cagney O, Ng JJ, Anderson JA, Williams C, Gerke BJ, Soliven B, Wollmann RL. Mutations in MUSK causing congenital myasthenic syndrome impair MuSK-Dok-7 interaction. Hum Mol Genet. 2010 Jun 15; 19(12):2370-9. View in: PubMed

  30. Douglas DS, Moran JL, Bermingham JR, Chen XJ, Brindley DN, Soliven B, Beier DR, Popko B. Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis. J Neurosci. 2009 Sep 30; 29(39):12089-100. View in: PubMed

  31. Kim HJ, Jung CG, Dukala D, Bae H, Kakazu R, Wollmann R, Soliven B. Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy. J Neuroimmunol. 2009 Sep 29; 214(1-2):93-100. View in: PubMed

  32. Kim HJ, Jung CG, Jensen MA, Dukala D, Soliven B. Targeting of myelin protein zero in a spontaneous autoimmune polyneuropathy. J Immunol. 2008 Dec 15; 181(12):8753-60. View in: PubMed

  33. Soliven B, Rezania K, Gundogdu B, Harding-Clay B, Oger J, Arnason BG. Terbutaline in myasthenia gravis: a pilot study. J Neurol Sci. 2009 Feb 15; 277(1-2):150-4. View in: PubMed

  34. Miron VE, Hall JA, Kennedy TE, Soliven B, Antel JP. Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod. Am J Pathol. 2008 Oct; 173(4):1143-52. View in: PubMed

  35. Roos RP, Soliven B, Goldenberg F, Badruddin A, Baron JM. An elderly patient with Bickerstaff brainstem encephalitis and transient episodes of brainstem dysfunction. Arch Neurol. 2008 Jun; 65(6):821-4. View in: PubMed

  36. Chen XJ, Levedakou EN, Millen KJ, Wollmann RL, Soliven B, Popko B. Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic Dynein heavy chain 1 gene. J Neurosci. 2007 Dec 26; 27(52):14515-24. View in: PubMed

  37. Miron VE, Jung CG, Kim HJ, Kennedy TE, Soliven B, Antel JP. FTY720 modulates human oligodendrocyte progenitor process extension and survival. Ann Neurol. 2008 Jan; 63(1):61-71. View in: PubMed

  38. Jung CG, Kim HJ, Miron VE, Cook S, Kennedy TE, Foster CA, Antel JP, Soliven B. Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells. Glia. 2007 Dec; 55(16):1656-67. View in: PubMed

  39. DeWitt MM, MacLeod HM, Soliven B, McNally EM. Phospholamban R14 deletion results in late-onset, mild, hereditary dilated cardiomyopathy. J Am Coll Cardiol. 2006 Oct 03; 48(7):1396-8. View in: PubMed

  40. Rezania K, Arnason BG, Soliven B. Patterns and significance of concomitant central and peripheral inflammatory demyelination. Neurol Res. 2006 Apr; 28(3):326-33. View in: PubMed

  41. Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT. Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. Nat Genet. 2006 Feb; 38(2):245-50. View in: PubMed

  42. Iwase T, Jung CG, Bae H, Zhang M, Soliven B. Glial cell line-derived neurotrophic factor-induced signaling in Schwann cells. J Neurochem. 2005 Sep; 94(6):1488-99. View in: PubMed

  43. Levedakou EN, Chen XJ, Soliven B, Popko B. Disruption of the mouse Large gene in the enr and myd mutants results in nerve, muscle, and neuromuscular junction defects. Mol Cell Neurosci. 2005 Apr; 28(4):757-69. View in: PubMed

  44. Bacia A, Wollmann R, Soliven B. K+ channel blockade impairs remyelination in the cuprizone model. Glia. 2004 Nov 01; 48(2):156-65. View in: PubMed

  45. Rezania K, Gundogdu B, Soliven B. Pathogenesis of chronic inflammatory demyelinating polyradiculoneuropathy. Front Biosci. 2004 Jan 01; 9:939-45. View in: PubMed

  46. Traka M, Goutebroze L, Denisenko N, Bessa M, Nifli A, Havaki S, Iwakura Y, Fukamauchi F, Watanabe K, Soliven B, Girault JA, Karagogeos D. Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. J Cell Biol. 2003 Sep 15; 162(6):1161-72. View in: PubMed

  47. Pytel P, Rezania K, Soliven B, Frank J, Wollmann R. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with hypertrophic spinal radiculopathy mimicking neurofibromatosis. Acta Neuropathol. 2003 Feb; 105(2):185-8. View in: PubMed

  48. Soliven B, Ma L, Bae H, Attali B, Sobko A, Iwase T. PDGF upregulates delayed rectifier via Src family kinases and sphingosine kinase in oligodendroglial progenitors. . 2003 Jan; 284(1):C85-93. View in: PubMed

  49. Salomon B, Rhee L, Bour-Jordan H, Hsin H, Montag A, Soliven B, Arcella J, Girvin AM, Padilla J, Miller SD, Bluestone JA. Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice. J Exp Med. 2001 Sep 03; 194(5):677-84. View in: PubMed

  50. Nagano S, Takeda M, Ma L, Soliven B. Cytokine-induced cell death in immortalized Schwann cells: roles of nitric oxide and cyclic AMP. J Neurochem. 2001 Jun; 77(6):1486-95. View in: PubMed

  51. Soliven B. Calcium signalling in cells of oligodendroglial lineage. Microsc Res Tech. 2001 Mar 15; 52(6):672-9. View in: PubMed

  52. Yu C, Takeda M, Soliven B. Regulation of cell cycle proteins by TNF-alpha and TGF-beta in cells of oligodendroglial lineage. J Neuroimmunol. 2000 Aug 01; 108(1-2):2-10. View in: PubMed

  53. Hida H, Nagano S, Takeda M, Soliven B. Regulation of mitogen-activated protein kinases by sphingolipid products in oligodendrocytes. J Neurosci. 1999 Sep 01; 19(17):7458-67. View in: PubMed

  54. Hida H, Takeda M, Soliven B. Ceramide inhibits inwardly rectifying K+ currents via a Ras- and Raf-1-dependent pathway in cultured oligodendrocytes. J Neurosci. 1998 Nov 01; 18(21):8712-9. View in: PubMed

  55. Takeda M, Soliven B. Arachidonic acid inhibits myelin basic protein phosphorylation in cultured oligodendrocytes. Glia. 1997 Nov; 21(3):277-84. View in: PubMed

  56. Soliven B, Dhand UK, Kobayashi K, Arora R, Martin B, Petersen MV, Janisch L, Vogelzang NJ, Vokes EE, Ratain MJ. Evaluation of neuropathy in patients on suramin treatment. Muscle Nerve. 1997 Jan; 20(1):83-91. View in: PubMed

  57. Soliven B, Takeda M, Shandy T, Nelson DJ. Arachidonic acid and its metabolites increase Cai in cultured rat oligodendrocytes. Am J Physiol. 1993 Mar; 264(3 Pt 1):C632-40. View in: PubMed

  58. Kim DH, Muthyala S, Soliven B, Wiegmann K, Wollmann R, Chelmicka-Schorr E. The beta 2-adrenergic agonist terbutaline suppresses experimental allergic neuritis in Lewis rats. J Neuroimmunol. 1994 May; 51(2):177-83. View in: PubMed

  59. Soliven B, Wang N. Tumor necrosis factor-alpha regulates nicotinic responses in mixed cultures of sympathetic neurons and nonneuronal cells. J Neurochem. 1995 Feb; 64(2):883-94. View in: PubMed

  60. Kobayashi K, Vokes EE, Vogelzang NJ, Janish L, Soliven B, Ratain MJ. Phase I study of suramin given by intermittent infusion without adaptive control in patients with advanced cancer. J Clin Oncol. 1995 Sep; 13(9):2196-207. View in: PubMed

  61. Soliven B, Wang N. Arachidonic acid inhibits potassium conductances in cultured rat oligodendrocytes. Am J Physiol. 1995 Aug; 269(2 Pt 1):C341-8. View in: PubMed

  62. Takeda M, Nelson DJ, Soliven B. Calcium signaling in cultured rat oligodendrocytes. Glia. 1995 Jul; 14(3):225-36. View in: PubMed

  63. Soliven B, Szuchet S. Signal transduction pathways in oligodendrocytes: role of tumor necrosis factor-alpha. Int J Dev Neurosci. 1995 Jun-Jul; 13(3-4):351-67. View in: PubMed

  64. Soliven B, Takeda M, Szuchet S. Depolarizing agents and tumor necrosis factor-alpha modulate protein phosphorylation in oligodendrocytes. J Neurosci Res. 1994 May 01; 38(1):91-100. View in: PubMed

  65. Soliven BC, Lange DJ, Penn AS, Younger D, Jaretzki A, Lovelace RE, Rowland LP. Seronegative myasthenia gravis. Neurology. 1988 Apr; 38(4):514-7. View in: PubMed

  66. Soliven B, Szuchet S, Arnason BG, Nelson DJ. Forskolin and phorbol esters decrease the same K+ conductance in cultured oligodendrocytes. J Membr Biol. 1988 Oct; 105(2):177-86. View in: PubMed

  67. Soliven B, Szuchet S, Arnason BG, Nelson DJ. Voltage-gated potassium currents in cultured ovine oligodendrocytes. J Neurosci. 1988 Jun; 8(6):2131-41. View in: PubMed

  68. Soliven B, Maselli R, Jaspan J, Green A, Graziano H, Petersen M, Spire JP. Sympathetic skin response in diabetic neuropathy. Muscle Nerve. 1987 Oct; 10(8):711-6. View in: PubMed

  69. Maselli RA, Jaspan JB, Soliven BC, Green AJ, Spire JP, Arnason BG. Comparison of sympathetic skin response with quantitative sudomotor axon reflex test in diabetic neuropathy. Muscle Nerve. 1989 May; 12(5):420-3. View in: PubMed

  70. Soliven B, Szuchet S, Arnason BG, Nelson DJ. Expression and modulation of K+ currents in oligodendrocytes: possible role in myelinogenesis. Dev Neurosci. 1989; 11(2):118-31. View in: PubMed

  71. Vartanian T, Dawson G, Soliven B, Nelson DJ, Szuchet S. Phosphorylation of myelin basic protein in intact oligodendrocytes: inhibition by galactosylsphingosine and cyclic AMP. Glia. 1989; 2(5):370-9. View in: PubMed

  72. Soliven B, Nelson DJ. Beta-adrenergic modulation of K+ current in human T lymphocytes. J Membr Biol. 1990 Sep; 117(3):263-74. View in: PubMed

  73. Soliven B, Albert J. Tumor necrosis factor modulates the inactivation of catecholamine secretion in cultured sympathetic neurons. J Neurochem. 1992 Mar; 58(3):1073-8. View in: PubMed

  74. Maselli RA, Soliven BC. Analysis of the organophosphate-induced electromyographic response to repetitive nerve stimulation: paradoxical response to edrophonium and D-tubocurarine. Muscle Nerve. 1991 Dec; 14(12):1182-8. View in: PubMed

  75. Soliven B, Szuchet S, Nelson DJ. Tumor necrosis factor inhibits K+ current expression in cultured oligodendrocytes. J Membr Biol. 1991 Nov; 124(2):127-37. View in: PubMed

  76. Soliven B, Maselli RA. Single motor unit H-reflex in motor neuron disorders. Muscle Nerve. 1992 Jun; 15(6):656-60. View in: PubMed

  77. Soliven B, Albert J. Tumor necrosis factor modulates Ca2+ currents in cultured sympathetic neurons. J Neurosci. 1992 Jul; 12(7):2665-71. View in: PubMed