Research Summary
Dr Marks focuses on the mechanisms and treatment of hypoxic-ischemic brain injury. A Neonatologist with a PhD in Neuroscience, his primary interest is in acute brain injury of the newborn. Currently, Dr. Marks's research focuses on A) the role of decreased cerebral autoregulation in newborns at risk hypoxic-ischemic brain injury, and B) mechanisms underlying the generation of abnormal spontaneous motor behavior in survivors of Hypoxic-Ischemic encephalopathy using functional MRI. Previously, his research focus in the laboratory was in mitochondrial mechanisms of acute neuronal degeneration and the mechanisms of membrane-targeted neuronal rescue by tri-block co-polymers of poly[ethylene oxide] and poly[propylene oxide].
Keywords
Hypoxic-Ischemic Encephalopathy, Hypoxia-Ischemia, Cerebral, fMRI, general movements, acute neurodegeneration, Near-Infrared Spectroscopy
Education
  • University of Toronto, Toronto, Ontario, Canada, BA . Linguistics 1979
  • University of Toronto, Toronto, Ontario, Canada, MA . Linguistics 1980
  • University of California, Los Angeles, Los Angeles, CA, PhD . Neuroscience: Sleep state regulation of upper airway control of breathing 1987
  • McMaster University, Hamilton, Ontario, Canada, MD . Medicine 1987
  • Boston University, Boston, MA, Residency . Pediatrics 1990
  • Yale University, New Haven, CT, Clinical fellowship (3 years) . Neonatal-Perinatal Medicine 1993
  • Yale University, New Haven CT, Post-doctoral fellowship (4 years) . Developmental regulation of vulnerability to hypoxic-ischemic brain injury in hippocampal neurons 1994
Biosciences Graduate Program Association
Publications
  1. Riehm JJ, Wang L, Ghadge G, Teng M, Correa AM, Marks JD, Roos RP, Allen MJ. Poloxamer 188 decreases membrane toxicity of mutant SOD1 and ameliorates pathology observed in SOD1 mouse model for ALS. Neurobiol Dis. 2018 07; 115:115-126. View in: PubMed

  2. Schreiber MD, Marks JD. Noninvasive Ventilation in the Premature Newborn - Is Less Always More? N Engl J Med. 2017 07 27; 377(4):386-388. View in: PubMed

  3. Wang JC, Bindokas VP, Skinner M, Emrick T, Marks JD. Mitochondrial mechanisms of neuronal rescue by F-68, a hydrophilic Pluronic block co-polymer, following acute substrate deprivation. Neurochem Int. 2017 Oct; 109:126-140. View in: PubMed

  4. Plant LD, Marks JD, Goldstein SA. SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons. Elife. 2016 12 28; 5. View in: PubMed

  5. Peyton C, Yang E, Msall ME, Adde L, Støen R, Fjørtoft T, Bos AF, Einspieler C, Zhou Y, Schreiber MD, Marks JD, Drobyshevsky A. White Matter Injury and General Movements in High-Risk Preterm Infants. AJNR Am J Neuroradiol. 2017 Jan; 38(1):162-169. View in: PubMed

  6. Chlenski A, Dobratic M, Salwen HR, Applebaum M, Guerrero LJ, Miller R, DeWane G, Solomaha E, Marks JD, Cohn SL. Secreted protein acidic and rich in cysteine (SPARC) induces lipotoxicity in neuroblastoma by regulating transport of albumin complexed with fatty acids. Oncotarget. 2016 Nov 22; 7(47):77696-77706. View in: PubMed

  7. Suresh J, Radojicic M, Pesce LL, Bhansali A, Wang J, Tryba AK, Marks JD, van Drongelen W. Network burst activity in hippocampal neuronal cultures: the role of synaptic and intrinsic currents. J Neurophysiol. 2016 06 01; 115(6):3073-89. View in: PubMed

  8. Muller AJ, Marks JD. Hypoxic ischemic brain injury: Potential therapeutic interventions for the future. Neoreviews. 2014 May 01; 15(5):e177-e186. View in: PubMed

  9. Waypa GB, Osborne SW, Marks JD, Berkelhamer SK, Kondapalli J, Schumacker PT. Sirtuin 3 deficiency does not augment hypoxia-induced pulmonary hypertension. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):885-91. View in: PubMed

  10. Sabharwal SS, Waypa GB, Marks JD, Schumacker PT. Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling. Biochem J. 2013 Dec 15; 456(3):337-46. View in: PubMed

  11. Shelat PB, Plant LD, Wang JC, Lee E, Marks JD. The membrane-active tri-block copolymer pluronic F-68 profoundly rescues rat hippocampal neurons from oxygen-glucose deprivation-induced death through early inhibition of apoptosis. J Neurosci. 2013 Jul 24; 33(30):12287-99. View in: PubMed

  12. Waypa GB, Marks JD, Guzy RD, Mungai PT, Schriewer JM, Dokic D, Ball MK, Schumacker PT. Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation. Am J Respir Crit Care Med. 2013 Feb 15; 187(4):424-32. View in: PubMed

  13. Plant LD, Zuniga L, Araki D, Marks JD, Goldstein SA. SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons. Sci Signal. 2012 Nov 20; 5(251):ra84. View in: PubMed

  14. Wang JY, Marks J, Lee KY. Nature of interactions between PEO-PPO-PEO triblock copolymers and lipid membranes: (I) effect of polymer hydrophobicity on its ability to protect liposomes from peroxidation. Biomacromolecules. 2012 Sep 10; 13(9):2616-23. View in: PubMed

  15. Marks JD, Schreiber MD. Individualized prediction of bronchopulmonary dysplasia risk: one step closer. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1584-6. View in: PubMed

  16. Plant LD, Dowdell EJ, Dementieva IS, Marks JD, Goldstein SA. SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons. J Gen Physiol. 2011 May; 137(5):441-54. View in: PubMed

  17. Patrianakos-Hoobler AI, Marks JD, Msall ME, Huo D, Schreiber MD. Safety and efficacy of inhaled nitric oxide treatment for premature infants with respiratory distress syndrome: follow-up evaluation at early school age. Acta Paediatr. 2011 Apr; 100(4):524-8. View in: PubMed

  18. Wang JY, Chin J, Marks JD, Lee KY. Effects of PEO-PPO-PEO triblock copolymers on phospholipid membrane integrity under osmotic stress. Langmuir. 2010 Aug 03; 26(15):12953-61. View in: PubMed

  19. Plant LD, Dementieva IS, Kollewe A, Olikara S, Marks JD, Goldstein SA. One SUMO is sufficient to silence the dimeric potassium channel K2P1. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10743-8. View in: PubMed

  20. Waypa GB, Marks JD, Guzy R, Mungai PT, Schriewer J, Dokic D, Schumacker PT. Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells. Circ Res. 2010 Feb 19; 106(3):526-35. View in: PubMed

  21. Patrianakos-Hoobler AI, Msall ME, Huo D, Marks JD, Plesha-Troyke S, Schreiber MD. Predicting school readiness from neurodevelopmental assessments at age 2 years after respiratory distress syndrome in infants born preterm. Dev Med Child Neurol. 2010 Apr; 52(4):379-85. View in: PubMed

  22. Desireddi JR, Farrow KN, Marks JD, Waypa GB, Schumacker PT. Hypoxia increases ROS signaling and cytosolic Ca(2+) in pulmonary artery smooth muscle cells of mouse lungs slices. Antioxid Redox Signal. 2010 Mar 01; 12(5):595-602. View in: PubMed

  23. Patrianakos-Hoobler AI, Msall ME, Marks JD, Huo D, Schreiber MD. Risk factors affecting school readiness in premature infants with respiratory distress syndrome. Pediatrics. 2009 Jul; 124(1):258-67. View in: PubMed

  24. Marks JD, Schreiber MD. Inhaled nitric oxide and neuroprotection in preterm infants. Clin Perinatol. 2008 Dec; 35(4):793-807, viii. View in: PubMed

  25. Claud EC, Lu J, Wang XQ, Abe M, Petrof EO, Sun J, Nelson DJ, Marks J, Jilling T. Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2008 May; 294(5):G1191-200. View in: PubMed

  26. Wang XQ, Deriy LV, Foss S, Huang P, Lamb FS, Kaetzel MA, Bindokas V, Marks JD, Nelson DJ. CLC-3 channels modulate excitatory synaptic transmission in hippocampal neurons. Neuron. 2006 Oct 19; 52(2):321-33. View in: PubMed

  27. Seal JB, Buchh BN, Marks JD. New variability in cerebrovascular anatomy determines severity of hippocampal injury following forebrain ischemia in the Mongolian gerbil. Brain Res. 2006 Feb 16; 1073-1074:451-9. View in: PubMed

  28. Mestan KK, Marks JD, Hecox K, Huo D, Schreiber MD. Neurodevelopmental outcomes of premature infants treated with inhaled nitric oxide. N Engl J Med. 2005 Jul 07; 353(1):23-32. View in: PubMed

  29. Kuznetsov A, Bindokas VP, Marks JD, Philipson LH. FRET-based voltage probes for confocal imaging: membrane potential oscillations throughout pancreatic islets. Am J Physiol Cell Physiol. 2005 Jul; 289(1):C224-9. View in: PubMed

  30. Kweon GR, Marks JD, Krencik R, Leung EH, Schumacker PT, Hyland K, Kang UJ. Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells. J Biol Chem. 2004 Dec 10; 279(50):51783-92. View in: PubMed

  31. Schreiber MD, Gin-Mestan K, Marks JD, Huo D, Lee G, Srisuparp P. Inhaled nitric oxide in premature infants with the respiratory distress syndrome. N Engl J Med. 2003 Nov 27; 349(22):2099-107. View in: PubMed

  32. Nakamura K, Bindokas VP, Kowlessur D, Elas M, Milstien S, Marks JD, Halpern HJ, Kang UJ. Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons. J Biol Chem. 2001 Sep 14; 276(37):34402-7. View in: PubMed

  33. Marks JD, Pan CY, Bushell T, Cromie W, Lee RC. Amphiphilic, tri-block copolymers provide potent membrane-targeted neuroprotection. FASEB J. 2001 Apr; 15(6):1107-9. View in: PubMed

  34. Marks JD, Bindokas VP, Zhang XM. Maturation of vulnerability to excitotoxicity: intracellular mechanisms in cultured postnatal hippocampal neurons. Brain Res Dev Brain Res. 2000 Nov 30; 124(1-2):101-16. View in: PubMed

  35. Nakamura K, Bindokas VP, Marks JD, Wright DA, Frim DM, Miller RJ, Kang UJ. The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited. Mol Pharmacol. 2000 Aug; 58(2):271-8. View in: PubMed