Research Summary
Dr. Keedy’s lab, the CENSL, focuses on cognitive and emotional neural systems - and their overlap - in psychiatric disorders. A major area of focus is psychotic disorders, and a major methodology is human neuroimaging.
psychosis, neuroimaging
  • Oklahoma State University, BS Psychology 1997
  • Rosalind Franklin University of Medicine and Science, PhD Clinical Psychology 2004
  • Jesse Brown VA Medical Center, Chicago, Internship Clinical Neuropsychology 2004
  • University of Illinois at Chicago, Postdoctoral Fellowship Neuropsychology, Psychopathology Research 2006
Biosciences Graduate Program Association
  1. Han J, Keedy S, Murray CH, Foxley S, de Wit H. Acute effects of alcohol on resting-state functional connectivity in healthy young men. Addict Behav. 2021 Apr; 115:106786. View in: PubMed

  2. Cremers H, Keedy S, Coccaro E. The development of an fMRI protocol to investigate vmPFC network functioning underlying the generalization of behavioral control. Psychiatry Res Neuroimaging. 2021 Jan 30; 307:111197. View in: PubMed

  3. Lizano P, Lutz O, Xu Y, Rubin LH, Paskowitz L, Lee AM, Eum S, Keedy SK, Hill SK, Reilly JL, Wu B, Tamminga CA, Clementz BA, Pearlson GD, Gershon ES, Keshavan MS, Sweeney JA, Bishop JR. Multivariate relationships between peripheral inflammatory marker subtypes and cognitive and brain structural measures in psychosis. Mol Psychiatry. 2020 Oct 15. View in: PubMed

  4. Tamminga CA, Clementz BA, Pearlson G, Keshavan M, Gershon ES, Ivleva EI, McDowell J, Meda SA, Keedy S, Calhoun VD, Lizano P, Bishop JR, Hudgens-Haney M, Alliey-Rodriguez N, Asif H, Gibbons R. Biotyping in psychosis: using multiple computational approaches with one data set. Neuropsychopharmacology. 2021 01; 46(1):143-155. View in: PubMed

  5. Hochberger WC, Eskridge CLM, Bishop JR, Reilly JL, Rubin LH, Keedy S, Gershon ES, Tamminga CA, Pearlson GD, Ragozzino M, Keshavan MS, Sweeney JA, Hill SK. Catechol-O-methyltransferase genotype differentially contributes to the flexibility and stability of cognitive sets in patients with psychotic disorders and their first-degree relatives. Schizophr Res. 2020 Sep; 223:236-241. View in: PubMed

  6. Okuneye VT, Meda S, Pearlson GD, Clementz BA, Keshavan MS, Tamminga CA, Ivleva E, Sweeney JA, Gershon ES, Keedy SK. Resting state auditory-language cortex connectivity is associated with hallucinations in clinical and biological subtypes of psychotic disorders. Neuroimage Clin. 2020; 27:102358. View in: PubMed

  7. Gotra MY, Hill SK, Gershon ES, Tamminga CA, Ivleva EI, Pearlson GD, Keshavan MS, Clementz BA, McDowell JE, Buckley PF, Sweeney JA, Keedy SK. Distinguishing patterns of impairment on inhibitory control and general cognitive ability among bipolar with and without psychosis, schizophrenia, and schizoaffective disorder. Schizophr Res. 2020 Sep; 223:148-157. View in: PubMed

  8. Herms EN, Bishop JR, Okuneye VT, Tamminga CA, Keshavan MS, Pearlson GD, Clementz BA, McDowell JE, Ivleva EI, Gershon ES, Sweeney JA, Keedy SK. No connectivity alterations for striatum, default mode, or salience network in association with self-reported antipsychotic medication dose in a large chronic patient group. Schizophr Res. 2020 Sep; 223:359-360. View in: PubMed

  9. Clementz BA, Trotti RL, Pearlson GD, Keshavan MS, Gershon ES, Keedy SK, Ivleva EI, McDowell JE, Tamminga CA. Testing Psychosis Phenotypes From Bipolar-Schizophrenia Network for Intermediate Phenotypes for Clinical Application: Biotype Characteristics and Targets. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 08; 5(8):808-818. View in: PubMed

  10. Asif H, Alliey-Rodriguez N, Keedy S, Tamminga CA, Sweeney JA, Pearlson G, Clementz BA, Keshavan MS, Buckley P, Liu C, Neale B, Gershon ES. GWAS significance thresholds for deep phenotyping studies can depend upon minor allele frequencies and sample size. Mol Psychiatry. 2020 Feb 17. View in: PubMed

  11. Hudgens-Haney ME, Clementz BA, Ivleva EI, Keshavan MS, Pearlson GD, Gershon ES, Keedy SK, Sweeney JA, Gaudoux F, Bunouf P, Canolle B, Tonner F, Gatti-McArthur S, Tamminga CA. Cognitive Impairment and Diminished Neural Responses Constitute a Biomarker Signature of Negative Symptoms in Psychosis. Schizophr Bull. 2020 Feb 11. View in: PubMed

  12. Bershad AK, Preller KH, Lee R, Keedy S, Wren-Jarvis J, Bremmer MP, de Wit H. Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 04; 5(4):461-467. View in: PubMed

  13. Blackburn KM, Ivleva EI, Weir RA, Kim M, Hopkins SC, Hudgens-Haney ME, Keedy SK, Gershon ES, Sweeney JA, Keshavan MS, Pearlson GD, Clementz BA, Tamminga CA, Vernino S. NMDA receptor antibody seropositivity in psychosis: A pilot study from the Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP). Schizophr Res. 2020 04; 218:318-320. View in: PubMed

  14. Zhang W, Lei D, Keedy SK, Ivleva EI, Eum S, Yao L, Tamminga CA, Clementz BA, Keshavan MS, Pearlson GD, Gershon ES, Bishop JR, Gong Q, Lui S, Sweeney JA. Brain gray matter network organization in psychotic disorders. Neuropsychopharmacology. 2020 03; 45(4):666-674. View in: PubMed

  15. Massa N, Owens AV, Harmon W, Bhattacharya A, Ivleva EI, Keedy S, Sweeney JA, Pearlson GD, Keshavan MS, Tamminga CA, Clementz BA, Duncan E. Relationship of prolonged acoustic startle latency to diagnosis and biotype in the bipolar-schizophrenia network on intermediate phenotypes (B-SNIP) cohort. Schizophr Res. 2020 02; 216:357-366. View in: PubMed

  16. Trotti RL, Parker DA, Sabatinelli D, Tamminga CA, Gershon ES, Keedy SK, Keshavan MS, Pearlson GD, Sweeney JA, McDowell JE, Clementz BA. Electrophysiological correlates of emotional scene processing in bipolar disorder. J Psychiatr Res. 2020 01; 120:83-90. View in: PubMed

  17. Alliey-Rodriguez N, Grey TA, Shafee R, Asif H, Lutz O, Bolo NR, Padmanabhan J, Tandon N, Klinger M, Reis K, Spring J, Coppes L, Zeng V, Hegde RR, Hoang DT, Bannai D, Nawaz U, Henson P, Liu S, Gage D, McCarroll S, Bishop JR, Hill S, Reilly JL, Lencer R, Clementz BA, Buckley P, Glahn DC, Meda SA, Narayanan B, Pearlson G, Keshavan MS, Ivleva EI, Tamminga C, Sweeney JA, Curtis D, Badner JA, Keedy S, Rapoport J, Liu C, Gershon ES. NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis. Transl Psychiatry. 2019 09 17; 9(1):230. View in: PubMed

  18. Weafer J, Van Hedger K, Keedy SK, Nwaokolo N, de Wit H. Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults. Addict Biol. 2020 05; 25(3):e12775. View in: PubMed

  19. Parker DA, Hamm JP, McDowell JE, Keedy SK, Gershon ES, Ivleva EI, Pearlson GD, Keshavan MS, Tamminga CA, Sweeney JA, Clementz BA. Auditory steady-state EEG response across the schizo-bipolar spectrum. Schizophr Res. 2019 07; 209:218-226. View in: PubMed

  20. Van Hedger K, Keedy SK, Schertz KE, Berman MG, de Wit H. Effects of methamphetamine on neural responses to visual stimuli. Psychopharmacology (Berl). 2019 Jun; 236(6):1741-1748. View in: PubMed

  21. Rubin LH, Li S, Yao L, Keedy SK, Reilly JL, Hill SK, Bishop JR, Sue Carter C, Pournajafi-Nazarloo H, Drogos LL, Gershon E, Pearlson GD, Tamminga CA, Clementz BA, Keshavan MS, Lui S, Sweeney JA. Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia. Schizophr Res. 2018 12; 202:173-179. View in: PubMed

  22. Lencer R, Yao L, Reilly JL, Keedy SK, McDowell JE, Keshavan MS, Pearlson GD, Tamminga CA, Gershon ES, Clementz BA, Lui S, Sweeney JA. Alterations in intrinsic fronto-thalamo-parietal connectivity are associated with cognitive control deficits in psychotic disorders. Hum Brain Mapp. 2019 01; 40(1):163-174. View in: PubMed

  23. Zhang W, Li S, Wang X, Gong Y, Yao L, Xiao Y, Liu J, Keedy SK, Gong Q, Sweeney JA, Lui S. Abnormal dynamic functional connectivity between speech and auditory areas in schizophrenia patients with auditory hallucinations. Neuroimage Clin. 2018; 19:918-924. View in: PubMed

  24. Fanning JR, Keedy S, Berman ME, Lee R, Coccaro EF. Neural Correlates of Aggressive Behavior in Real Time: a Review of fMRI Studies of Laboratory Reactive Aggression. Curr Behav Neurosci Rep. 2017 Jun; 4(2):138-150. View in: PubMed

  25. Van Hedger K, Keedy SK, Mayo LM, Heilig M, de Wit H. Neural responses to cues paired with methamphetamine in healthy volunteers. Neuropsychopharmacology. 2018 07; 43(8):1732-1737. View in: PubMed

  26. Goldschmidt AB, Dickstein DP, MacNamara AE, Phan KL, O'Brien S, Le Grange D, Fisher JO, Keedy S. A Pilot Study of Neural Correlates of Loss of Control Eating in Children With Overweight/Obesity: Probing Intermittent Access to Food as a Means of Eliciting Disinhibited Eating. J Pediatr Psychol. 2018 09 01; 43(8):846-855. View in: PubMed

  27. Coccaro EF, Cremers H, Fanning J, Nosal E, Lee R, Keedy S, Jacobson KC. Reduced frontal grey matter, life history of aggression, and underlying genetic influence. Psychiatry Res Neuroimaging. 2018 01 30; 271:126-134. View in: PubMed

  28. Gershon ES, Pearlson G, Keshavan MS, Tamminga C, Clementz B, Buckley PF, Alliey-Rodriguez N, Liu C, Sweeney JA, Keedy S, Meda SA, Tandon N, Shafee R, Bishop JR, Ivleva EI. Genetic analysis of deep phenotyping projects in common disorders. Schizophr Res. 2018 05; 195:51-57. View in: PubMed

  29. Hudgens-Haney ME, Ethridge LE, McDowell JE, Keedy SK, Pearlson GD, Tamminga CA, Keshavan MS, Sweeney JA, Clementz BA. Psychosis subgroups differ in intrinsic neural activity but not task-specific processing. Schizophr Res. 2018 05; 195:222-230. View in: PubMed

  30. Rosen C, Jones N, Longden E, Chase KA, Shattell M, Melbourne JK, Keedy SK, Sharma RP. Exploring the Intersections of Trauma, Structural Adversity, and Psychosis among a Primarily African-American Sample: A Mixed-Methods Analysis. Front Psychiatry. 2017; 8:57. View in: PubMed

  31. Hudgens-Haney ME, Ethridge LE, Knight JB, McDowell JE, Keedy SK, Pearlson GD, Tamminga CA, Keshavan MS, Sweeney JA, Clementz BA. Intrinsic neural activity differences among psychotic illnesses. Psychophysiology. 2017 Aug; 54(8):1223-1238. View in: PubMed

  32. Eum S, Hill SK, Rubin LH, Carnahan RM, Reilly JL, Ivleva EI, Keedy SK, Tamminga CA, Pearlson GD, Clementz BA, Gershon ES, Keshavan MS, Keefe RSE, Sweeney JA, Bishop JR. Cognitive burden of anticholinergic medications in psychotic disorders. Schizophr Res. 2017 12; 190:129-135. View in: PubMed

  33. Rubin LH, Yao L, Keedy SK, Reilly JL, Bishop JR, Carter CS, Pournajafi-Nazarloo H, Drogos LL, Tamminga CA, Pearlson GD, Keshavan MS, Clementz BA, Hill SK, Liao W, Ji GJ, Lui S, Sweeney JA. Sex differences in associations of arginine vasopressin and oxytocin with resting-state functional brain connectivity. J Neurosci Res. 2017 01 02; 95(1-2):576-586. View in: PubMed

  34. Coccaro EF, Keedy SK, Gorka SM, King AC, Fanning JR, Lee RJ, Phan KL. Differential fMRI BOLD responses in amygdala in intermittent explosive disorder as a function of past Alcohol Use Disorder. Psychiatry Res Neuroimaging. 2016 Nov 30; 257:5-10. View in: PubMed

  35. Coccaro EF, Fanning JR, Keedy SK, Lee RJ. Social cognition in Intermittent Explosive Disorder and aggression. J Psychiatr Res. 2016 12; 83:140-150. View in: PubMed

  36. Lee R, Arfanakis K, Evia AM, Fanning J, Keedy S, Coccaro EF. White Matter Integrity Reductions in Intermittent Explosive Disorder. Neuropsychopharmacology. 2016 10; 41(11):2697-703. View in: PubMed

  37. McCloskey MS, Phan KL, Angstadt M, Fettich KC, Keedy S, Coccaro EF. Amygdala hyperactivation to angry faces in intermittent explosive disorder. J Psychiatr Res. 2016 08; 79:34-41. View in: PubMed

  38. Rubin LH, Connelly JJ, Reilly JL, Carter CS, Drogos LL, Pournajafi-Nazarloo H, Ruocco AC, Keedy SK, Matthew I, Tandon N, Pearlson GD, Clementz BA, Tamminga CA, Gershon ES, Keshavan MS, Bishop JR, Sweeney JA. Sex and diagnosis specific associations between DNA methylation of the oxytocin receptor gene with emotion processing and temporal-limbic and prefrontal brain volumes in psychotic disorders. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Mar 01; 1(2):141-151. View in: PubMed

  39. Cremers H, Lee R, Keedy S, Phan KL, Coccaro E. Effects of Escitalopram Administration on Face Processing in Intermittent Explosive Disorder: An fMRI Study. Neuropsychopharmacology. 2016 Jan; 41(2):590-7. View in: PubMed

  40. Keedy SK, Bishop JR, Weiden PJ, Sweeney JA, Rosen C, Marvin R, Reilly JL. Disease and drug effects on internally-generated and externally-elicited responses in first episode schizophrenia and psychotic bipolar disorder. Schizophr Res. 2014 Oct; 159(1):101-6. View in: PubMed

  41. Lui S, Yao L, Xiao Y, Keedy SK, Reilly JL, Keefe RS, Tamminga CA, Keshavan MS, Pearlson GD, Gong Q, Sweeney JA. Resting-state brain function in schizophrenia and psychotic bipolar probands and their first-degree relatives. Psychol Med. 2015 Jan; 45(1):97-108. View in: PubMed

  42. Woodward TS, Jung K, Hwang H, Yin J, Taylor L, Menon M, Peters E, Kuipers E, Waters F, Lecomte T, Sommer IE, Daalman K, van Lutterveld R, Hubl D, Kindler J, Homan P, Badcock JC, Chhabra S, Cella M, Keedy S, Allen P, Mechelli A, Preti A, Siddi S, Erickson D. Symptom dimensions of the psychotic symptom rating scales in psychosis: a multisite study. Schizophr Bull. 2014 Jul; 40 Suppl 4:S265-74. View in: PubMed

  43. Keedy SK, Reilly JL, Bishop JR, Weiden PJ, Sweeney JA. Impact of antipsychotic treatment on attention and motor learning systems in first-episode schizophrenia. Schizophr Bull. 2015 Mar; 41(2):355-65. View in: PubMed

  44. Ford JM, Morris SE, Hoffman RE, Sommer I, Waters F, McCarthy-Jones S, Thoma RJ, Turner JA, Keedy SK, Badcock JC, Cuthbert BN. Studying hallucinations within the NIMH RDoC framework. Schizophr Bull. 2014 Jul; 40 Suppl 4:S295-304. View in: PubMed

  45. Rubin LH, Carter CS, Bishop JR, Pournajafi-Nazarloo H, Drogos LL, Hill SK, Ruocco AC, Keedy SK, Reilly JL, Keshavan MS, Pearlson GD, Tamminga CA, Gershon ES, Sweeney JA. Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders. Schizophr Bull. 2014 Nov; 40(6):1374-84. View in: PubMed

  46. Wang J, Mathalon DH, Roach BJ, Reilly J, Keedy SK, Sweeney JA, Ford JM. Action planning and predictive coding when speaking. Neuroimage. 2014 May 01; 91:91-8. View in: PubMed

  47. Ford JM, Mathalon DH, Roach BJ, Keedy SK, Reilly JL, Gershon ES, Sweeney JA. Neurophysiological evidence of corollary discharge function during vocalization in psychotic patients and their nonpsychotic first-degree relatives. Schizophr Bull. 2013 Nov; 39(6):1272-80. View in: PubMed

  48. Rosen C, Marvin R, Reilly JL, Deleon O, Harris MS, Keedy SK, Solari H, Weiden P, Sweeney JA. Phenomenology of first-episode psychosis in schizophrenia, bipolar disorder, and unipolar depression: a comparative analysis. Clin Schizophr Relat Psychoses. 2012 Oct; 6(3):145-51. View in: PubMed

  49. Lu LH, Zhou XJ, Fitzgerald J, Keedy SK, Reilly JL, Passarotti AM, Sweeney JA, Pavuluri M. Microstructural abnormalities of white matter differentiate pediatric and adult-onset bipolar disorder. Bipolar Disord. 2012 Sep; 14(6):597-606. View in: PubMed

  50. Ethridge LE, Hamm JP, Shapiro JR, Summerfelt AT, Keedy SK, Stevens MC, Pearlson G, Tamminga CA, Boutros NN, Sweeney JA, Keshavan MS, Thaker G, Clementz BA. Neural activations during auditory oddball processing discriminating schizophrenia and psychotic bipolar disorder. Biol Psychiatry. 2012 Nov 01; 72(9):766-74. View in: PubMed

  51. Lu LH, Zhou XJ, Keedy SK, Reilly JL, Sweeney JA. White matter microstructure in untreated first episode bipolar disorder with psychosis: comparison with schizophrenia. Bipolar Disord. 2011 Nov-Dec; 13(7-8):604-13. View in: PubMed

  52. Lencer R, Keedy SK, Reilly JL, McDonough BE, Harris MS, Sprenger A, Sweeney JA. Altered transfer of visual motion information to parietal association cortex in untreated first-episode psychosis: implications for pursuit eye tracking. Psychiatry Res. 2011 Oct 31; 194(1):30-8. View in: PubMed

  53. Goldman MB, Wang L, Wachi C, Daudi S, Csernansky J, Marlow-O'Connor M, Keedy S, Torres I. Structural pathology underlying neuroendocrine dysfunction in schizophrenia. Behav Brain Res. 2011 Mar 17; 218(1):106-13. View in: PubMed

  54. Clementz BA, Gao Y, McDowell JE, Moratti S, Keedy SK, Sweeney JA. Top-down control of visual sensory processing during an ocular motor response inhibition task. Psychophysiology. 2010 Nov; 47(6):1011-8. View in: PubMed

  55. Torres IJ, Keedy S, Marlow-O'Connor M, Beenken B, Goldman MB. Neuropsychological impairment in patients with schizophrenia and evidence of hyponatremia and polydipsia. Neuropsychology. 2009 May; 23(3):307-14. View in: PubMed

  56. Ramati A, Pliskin NH, Keedy S, Erwin RJ, Fink JW, Bodnar EN, Lee RC, Cooper MA, Kelley K, Sweeney JA. Alteration in functional brain systems after electrical injury. J Neurotrauma. 2009 Oct; 26(10):1815-22. View in: PubMed

  57. Keedy SK, Rosen C, Khine T, Rajarethinam R, Janicak PG, Sweeney JA. An fMRI study of visual attention and sensorimotor function before and after antipsychotic treatment in first-episode schizophrenia. Psychiatry Res. 2009 Apr 30; 172(1):16-23. View in: PubMed

  58. Reilly JL, Lencer R, Bishop JR, Keedy S, Sweeney JA. Pharmacological treatment effects on eye movement control. Brain Cogn. 2008 Dec; 68(3):415-35. View in: PubMed

  59. Sweeney JA, Luna B, Keedy SK, McDowell JE, Clementz BA. fMRI studies of eye movement control: investigating the interaction of cognitive and sensorimotor brain systems. Neuroimage. 2007; 36 Suppl 2:T54-60. View in: PubMed

  60. Goldman MB, Torres IJ, Keedy S, Marlow-O'Connor M, Beenken B, Pilla R. Reduced anterior hippocampal formation volume in hyponatremic schizophrenic patients. Hippocampus. 2007; 17(7):554-62. View in: PubMed

  61. Keedy SK, Marlow-O'Connor M, Beenken B, Dorflinger J, Abel M, Erwin RJ. Noradrenergic antagonism of the P13 and N40 components of the rat auditory evoked potential. Psychopharmacology (Berl). 2007 Jan; 190(1):117-25. View in: PubMed

  62. Keedy SK, Ebens CL, Keshavan MS, Sweeney JA. Functional magnetic resonance imaging studies of eye movements in first episode schizophrenia: smooth pursuit, visually guided saccades and the oculomotor delayed response task. Psychiatry Res. 2006 Apr 30; 146(3):199-211. View in: PubMed