The de Wit laboratory investigates the subjective, behavioral and physiological effects of drugs of abuse in healthy human volunteers. Some studies are designed to identify individual differences and risk factors for excessive use, and others to determine the effects of drugs on mood, psychomotor and cognitive performance, and brain activity. Another major interest is the study of conditioned drug effects, or cues, that influence future drug use.
Concordia University
Montreal Canada
PhD - Experimental Psychology
1981
University of Calgary
Calgary Canada
BA - Psychology
1969
The empathogen 3,4-methylenedioxymethamphetamine, but not methamphetamine, increases feelings of global trust.
The empathogen 3,4-methylenedioxymethamphetamine, but not methamphetamine, increases feelings of global trust. J Psychopharmacol. 2025 Sep 16; 2698811251370999.
PMID: 40958371
The mesocorticolimbic system in stimulant use disorder.
The mesocorticolimbic system in stimulant use disorder. Mol Psychiatry. 2025 Nov; 30(11):5486-5499.
PMID: 40926091
Connectome-based encoding of subjective drug responses to acute oral methamphetamine.
Connectome-based encoding of subjective drug responses to acute oral methamphetamine. Neuropsychopharmacology. 2025 Nov; 50(12):1787-1794.
PMID: 40866561
How it begins: Initial response to opioids strongly predicts self-reported opioid use disorder.
How it begins: Initial response to opioids strongly predicts self-reported opioid use disorder. medRxiv. 2025 Aug 05.
PMID: 40166554
Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance.
Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance. Elife. 2025 Jul 21; 13.
PMID: 40689876
Effects of methamphetamine on human effort task performance are unrelated to its subjective effects.
Effects of methamphetamine on human effort task performance are unrelated to its subjective effects. Psychopharmacology (Berl). 2026 Jan; 243(1):199-209.
PMID: 40627130
Methamphetamine modulates functional connectivity signatures of sustained attention and arousal.
Methamphetamine modulates functional connectivity signatures of sustained attention and arousal. bioRxiv. 2025 May 21.
PMID: 40475570
Prescription Opioid Medication Survey: A Tool to Collect Deep Phenotypic Data on the Multifactorial Pathways to Opioid Use Disorder in Clinical and Population-Based Cohorts.
Prescription Opioid Medication Survey: A Tool to Collect Deep Phenotypic Data on the Multifactorial Pathways to Opioid Use Disorder in Clinical and Population-Based Cohorts. Complex Psychiatry. 2025 Jan-Dec; 11(1):72-93.
PMID: 40621581
Effects of methamphetamine on two measures of reward: Euphoria and neural activation to reward cues.
Effects of methamphetamine on two measures of reward: Euphoria and neural activation to reward cues. Neuropsychopharmacology. 2025 Jul; 50(8):1298-1304.
PMID: 40269142
Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance.
Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance. bioRxiv. 2025 Mar 20.
PMID: 39026741
Lifetime Achievement Award
Research Society on Alcoholism
2020
John F. Lemieux Medal for Distinguished Alumni
Concordia University, Montreal
2020
Distinguished Achievement Award
European Behavioural Pharmacology Society
2019
Distinguished Lecturer, Elizabeth Fitzgerald Sporar Endowment Distinguished Initiatives in Addiction
University of Texas
2016
Marian W. Fischman Memorial Lectureship Award
College of Problems on Drug Dependence
2009
Solvay Award for Outstanding Basic Psychopharmacological Research in Affective Disorders
American Psychological Association
1999