Faculty and Trainers

Mark Sheffield, PhD

We use optical techniques to measure and manipulate the activity of cells and circuits in the brain involved in the formation and recall of complex memories. We use mice as our animal model, and virtual reality as a platform for learning and memory related tasks. Our goal is to understand how the brain forms and recalls memories at the scale of synapses and dendrites through to the level of large ensembles of neurons and across brain regions.

Northwestern University
Evanston, USA
- Postdoc - Neurobiology
2017

Northwestern University
Evanston, USA
Ph. D. - Neurobiology
2011

University of Nottingham
Nottingham, England
BSc/Msc - Neuroscience
2006

Distinct CA3 inputs differentially shape the learning-dependent evolution of right CA1 spatial maps.
Distinct CA3 inputs differentially shape the learning-dependent evolution of right CA1 spatial maps. Nat Commun. 2026 Apr 28; 17(1).
PMID: 42049756

Behavioral Timescale Synaptic Plasticity: A Burst in the Field of Learning and Memory.
Behavioral Timescale Synaptic Plasticity: A Burst in the Field of Learning and Memory. J Neurosci. 2025 11 12; 45(46).
PMID: 41224656

Learning-Dependent Shift from Right to Left CA3 Input Dominance Shapes the Evolution of Right CA1 Spatial Maps.
Learning-Dependent Shift from Right to Left CA3 Input Dominance Shapes the Evolution of Right CA1 Spatial Maps. bioRxiv. 2025 Oct 27.
PMID: 41279309

A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality.
A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality. Elife. 2025 Jun 17; 14.
PMID: 40525399

A Preprocessing Toolbox for 2-Photon Subcellular Calcium Imaging.
A Preprocessing Toolbox for 2-Photon Subcellular Calcium Imaging. eNeuro. 2025 May; 12(5).
PMID: 40360280

A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality.
A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality. bioRxiv. 2025 Apr 13.
PMID: 39651122

Synaptic plasticity rules driving representational shifting in the hippocampus.
Synaptic plasticity rules driving representational shifting in the hippocampus. Nat Neurosci. 2025 Apr; 28(4):848-860.
PMID: 40113934

A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality.
A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality. bioRxiv. 2024 Nov 27.
PMID: 39651122

A preprocessing toolbox for 2-photon subcellular calcium imaging.
A preprocessing toolbox for 2-photon subcellular calcium imaging. bioRxiv. 2024 Nov 21.
PMID: 39605689

Distinct catecholaminergic pathways projecting to hippocampal CA1 transmit contrasting signals during navigation in familiar and novel environments.
Distinct catecholaminergic pathways projecting to hippocampal CA1 transmit contrasting signals during navigation in familiar and novel environments. Elife. 2024 Nov 06; 13.
PMID: 39504262

View All Publications

Sloan
2018 - 2020

Searle scholars program
2018 - 2021

DP2 - New Innovator Award
NIH
2018 - 2023

Whitehall Foundation
2017 - 2020