Alfredo Garcia

Assistant Professor
Websites
Research Summary
My research is focused on understanding how local brain circuit physiology is impacted by changes in blood gas homeostasis. We study the hippocampus, a brain region important to learning and memory, and brainstem networks involved cardio-respiratory control.
Keywords
Hypoxia, Adult Neurogenesis, Sleep Apnea, Synaptic plasticity
Education
  • The Ohio State University, Columbus, Ohio, B.Sc. Biological Science 06/1999
  • Wright State University, Dayton, Ohio, Ph.D. Biomedical Science 05/2006
  • The University of Chicago, Chicago, Illinois, Postdoctoral Fellowship Neuroscience 06/2009
Biosciences Graduate Program Association
Publications
  1. Alzate-Correa D, Liu J, Jones M, Silva TM, Alves MJ, Burke E, Zuñiga J, Kaya B, Zaza G, Aslan MT, Blackburn J, Shimada MY, Fernandes-Junior SA, Baer LA, Stanford KI, Kempton A, Smith S, Szujewski CC, Silbaugh A, Viemari JC, Takakura AC, Garcia AJ, Moreira TS, Czeisler CM, Otero JJ. Neonatal Apneic Phenotype in a Murine Congenital Central Hypoventilation Syndrome Model is Induced Through Non-Cell Autonomous Developmental Mechanisms. Brain Pathol. 2020 Jul 12. View in: PubMed

  2. Arias-Cavieres A, Khuu MA, Nwakudu CU, Barnard JE, Dalgin G, Garcia AJ. A HIF1a-Dependent Pro-Oxidant State Disrupts Synaptic Plasticity and Impairs Spatial Memory in Response to Intermittent Hypoxia. eNeuro. 2020 May/Jun; 7(3). View in: PubMed

  3. Garcia AJ, Szujewski CC. Finding inspiration in opioid-induced respiratory depression. J Physiol. 2020 01; 598(1):3. View in: PubMed

  4. Garcia AJ, Viemari JC, Khuu MA. Respiratory rhythm generation, hypoxia, and oxidative stress-Implications for development. Respir Physiol Neurobiol. 2019 12; 270:103259. View in: PubMed

  5. Khuu MA, Pagan CM, Nallamothu T, Hevner RF, Hodge RD, Ramirez JM, Garcia AJ. Intermittent Hypoxia Disrupts Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus. J Neurosci. 2019 02 13; 39(7):1320-1331. View in: PubMed

  6. Garcia AJ, Dashevskiy T, Khuu MA, Ramirez JM. Chronic Intermittent Hypoxia Differentially Impacts Different States of Inspiratory Activity at the Level of the preBötzinger Complex. Front Physiol. 2017; 8:571. View in: PubMed

  7. Harris KD, Dashevskiy T, Mendoza J, Garcia AJ, Ramirez JM, Shea-Brown E. Different roles for inhibition in the rhythm-generating respiratory network. J Neurophysiol. 2017 10 01; 118(4):2070-2088. View in: PubMed

  8. Garcia AJ, Ramirez JM. Keeping carbon dioxide in check. Elife. 2017 05 17; 6. View in: PubMed

  9. Anderson TM, Garcia AJ, Baertsch NA, Pollak J, Bloom JC, Wei AD, Rai KG, Ramirez JM. A novel excitatory network for the control of breathing. Nature. 2016 08 04; 536(7614):76-80. View in: PubMed

  10. Garcia AJ, Zanella S, Dashevskiy T, Khan SA, Khuu MA, Prabhakar NR, Ramirez JM. Chronic Intermittent Hypoxia Alters Local Respiratory Circuit Function at the Level of the preBötzinger Complex. Front Neurosci. 2016; 10:4. View in: PubMed

  11. Koch H, Caughie C, Elsen FP, Doi A, Garcia AJ, Zanella S, Ramirez JM. Prostaglandin E2 differentially modulates the central control of eupnoea, sighs and gasping in mice. J Physiol. 2015 01 01; 593(1):305-19. View in: PubMed

  12. Ramirez JM, Anderson TM, Garcia AJ. The ins and outs of breathing. Elife. 2014 Jun 17; 3:e03375. View in: PubMed

  13. Zanella S, Doi A, Garcia AJ, Elsen F, Kirsch S, Wei AD, Ramirez JM. When norepinephrine becomes a driver of breathing irregularities: how intermittent hypoxia fundamentally alters the modulatory response of the respiratory network. J Neurosci. 2014 Jan 01; 34(1):36-50. View in: PubMed

  14. Viemari JC, Garcia AJ, Doi A, Elsen G, Ramirez JM. ß-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro. Front Neural Circuits. 2013; 7:179. View in: PubMed

  15. Ramirez JM, Garcia AJ, Anderson TM, Koschnitzky JE, Peng YJ, Kumar GK, Prabhakar NR. Central and peripheral factors contributing to obstructive sleep apneas. Respir Physiol Neurobiol. 2013 Nov 01; 189(2):344-53. View in: PubMed

  16. Garcia AJ, Koschnitzky JE, Ramirez JM. The physiological determinants of sudden infant death syndrome. Respir Physiol Neurobiol. 2013 Nov 01; 189(2):288-300. View in: PubMed

  17. Garcia AJ, Rotem-Kohavi N, Doi A, Ramirez JM. Post-hypoxic recovery of respiratory rhythm generation is gender dependent. PLoS One. 2013; 8(4):e60695. View in: PubMed

  18. Garcia AJ, Koschnitzky JE, Dashevskiy T, Ramirez JM. Cardiorespiratory coupling in health and disease. Auton Neurosci. 2013 Apr; 175(1-2):26-37. View in: PubMed

  19. Hodge RD, Garcia AJ, Elsen GE, Nelson BR, Mussar KE, Reiner SL, Ramirez JM, Hevner RF. Tbr2 expression in Cajal-Retzius cells and intermediate neuronal progenitors is required for morphogenesis of the dentate gyrus. J Neurosci. 2013 Feb 27; 33(9):4165-80. View in: PubMed

  20. Koch H, Zanella S, Elsen GE, Smith L, Doi A, Garcia AJ, Wei AD, Xun R, Kirsch S, Gomez CM, Hevner RF, Ramirez JM. Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels. J Neurosci. 2013 Feb 20; 33(8):3633-45. View in: PubMed

  21. Ramirez JM, Koch H, Garcia AJ, Doi A, Zanella S. The role of spiking and bursting pacemakers in the neuronal control of breathing. J Biol Phys. 2011 Jun; 37(3):241-61. View in: PubMed

  22. Madisen L, Mao T, Koch H, Zhuo JM, Berenyi A, Fujisawa S, Hsu YW, Garcia AJ, Gu X, Zanella S, Kidney J, Gu H, Mao Y, Hooks BM, Boyden ES, Buzsáki G, Ramirez JM, Jones AR, Svoboda K, Han X, Turner EE, Zeng H. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci. 2012 Mar 25; 15(5):793-802. View in: PubMed

  23. Koch H, Garcia AJ, Ramirez JM. Network reconfiguration and neuronal plasticity in rhythm-generating networks. Integr Comp Biol. 2011 Dec; 51(6):856-68. View in: PubMed

  24. Garcia AJ, Khan SA, Kumar GK, Prabhakar NR, Ramirez JM. Hydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus. J Neurophysiol. 2011 Dec; 106(6):3045-55. View in: PubMed

  25. Viemari JC, Garcia AJ, Doi A, Ramirez JM. Activation of alpha-2 noradrenergic receptors is critical for the generation of fictive eupnea and fictive gasping inspiratory activities in mammals in vitro. Eur J Neurosci. 2011 Jun; 33(12):2228-37. View in: PubMed

  26. Garcia AJ, Zanella S, Koch H, Doi A, Ramirez JM. Chapter 3--networks within networks: the neuronal control of breathing. Prog Brain Res. 2011; 188:31-50. View in: PubMed

  27. Hill AA, Garcia AJ, Zanella S, Upadhyaya R, Ramirez JM. Graded reductions in oxygenation evoke graded reconfiguration of the isolated respiratory network. J Neurophysiol. 2011 Feb; 105(2):625-39. View in: PubMed

  28. Garcia AJ, Putnam RW, Dean JB. Hyperbaric hyperoxia and normobaric reoxygenation increase excitability and activate oxygen-induced potentiation in CA1 hippocampal neurons. J Appl Physiol (1985). 2010 Sep; 109(3):804-19. View in: PubMed

  29. Garcia AJ, Putnam RW, Dean JB. Hyperoxic stimulation of synchronous orthodromic activity and induction of neural plasticity does not require changes in excitatory synaptic transmission. J Appl Physiol (1985). 2010 Sep; 109(3):820-9. View in: PubMed

  30. Ramirez JM, Garcia A. Point: Medullary pacemaker neurons are essential for both eupnea and gasping in mammals. J Appl Physiol (1985). 2007 Aug; 103(2):717-8; discussion 722. View in: PubMed

  31. Dean JB, Mulkey DK, Garcia AJ, Putnam RW, Henderson RA. Neuronal sensitivity to hyperoxia, hypercapnia, and inert gases at hyperbaric pressures. J Appl Physiol (1985). 2003 Sep; 95(3):883-909. View in: PubMed