Harriet de Wit

Professor
Websites
Research Summary
The de Wit laboratory investigates the subjective, behavioral and physiological effects of drugs of abuse in healthy human volunteers. Some studies are designed to identify individual differences and risk factors for excessive use, and others to determine the effects of drugs on mood, psychomotor and cognitive performance, and brain activity. Another major interest is the study of conditioned drug effects, or cues, that influence future drug use.
Keywords
Human, Addiction, Substance, Mood, Reward, Conditioning (Psychology), Imaging, Magnetic Resonance, Psychopharmacology, Inhibition (Psychology)
Education
  • University of Calgary, Calgary Canada, BA Psychology 1969
  • Concordia University, Montreal Canada, PhD Experimental Psychology 02/1981
Biosciences Graduate Program Association
Awards & Honors
  • 1999 - Solvay Award for Outstanding Basic Psychopharmacological Research in Affective Disorders American Psychological Association
  • 2009 - Marian W. Fischman Memorial Lectureship Award College of Problems on Drug Dependence
  • 2016 - Distinguished Lecturer, Elizabeth Fitzgerald Sporar Endowment Distinguished Initiatives in Addiction University of Texas
  • 2019 - Distinguished Achievement Award European Behavioural Pharmacology Society
  • 2020 - John F. Lemieux Medal for Distinguished Alumni Concordia University, Montreal
  • 2020 - Lifetime Achievement Award Research Society on Alcoholism
Publications
  1. Radoman M, Crane NA, Gorka SM, Weafer J, Langenecker SA, de Wit H, Phan KL. Striatal activation to monetary reward is associated with alcohol reward sensitivity. Neuropsychopharmacology. 2020 Jun 06. View in: PubMed

  2. Murray CH, Weafer J, de Wit H. Stability of acute responses to drugs in humans across repeated testing: Findings with alcohol and amphetamine. Drug Alcohol Depend. 2020 Jul 01; 212:107989. View in: PubMed

  3. Adam KCS, Doss MK, Pabon E, Vogel EK, de Wit H. ?9-Tetrahydrocannabinol (THC) impairs visual working memory performance: a randomized crossover trial. Neuropsychopharmacology. 2020 May 09. View in: PubMed

  4. Munn-Chernoff MA, Johnson EC, Chou YL, Coleman JRI, Thornton LM, Walters RK, Yilmaz Z, Baker JH, Hübel C, Gordon S, Medland SE, Watson HJ, Gaspar HA, Bryois J, Hinney A, Leppä VM, Mattheisen M, Ripke S, Yao S, Giusti-Rodríguez P, Hanscombe KB, Adan RAH, Alfredsson L, Ando T, Andreassen OA, Berrettini WH, Boehm I, Boni C, Boraska Perica V, Buehren K, Burghardt R, Cassina M, Cichon S, Clementi M, Cone RD, Courtet P, Crow S, Crowley JJ, Danner UN, Davis OSP, de Zwaan M, Dedoussis G, Degortes D, DeSocio JE, Dick DM, Dikeos D, Dina C, Dmitrzak-Weglarz M, Docampo E, Duncan LE, Egberts K, Ehrlich S, Escaramís G, Esko T, Estivill X, Farmer A, Favaro A, Fernández-Aranda F, Fichter MM, Fischer K, Föcker M, Foretova L, Forstner AJ, Forzan M, Franklin CS, Gallinger S, Giegling I, Giuranna J, Gonidakis F, Gorwood P, Gratacos Mayora M, Guillaume S, Guo Y, Hakonarson H, Hatzikotoulas K, Hauser J, Hebebrand J, Helder SG, Herms S, Herpertz-Dahlmann B, Herzog W, Huckins LM, Hudson JI, Imgart H, Inoko H, Janout V, Jiménez-Murcia S, Julià A, Kalsi G, Kaminská D, Karhunen L, Karwautz A, Kas MJH, Kennedy JL, Keski-Rahkonen A, Kiezebrink K, Kim YR, Klump KL, Knudsen GPS, La Via MC, Le Hellard S, Levitan RD, Li D, Lilenfeld L, Lin BD, Lissowska J, Luykx J, Magistretti PJ, Maj M, Mannik K, Marsal S, Marshall CR, Mattingsdal M, McDevitt S, McGuffin P, Metspalu A, Meulenbelt I, Micali N, Mitchell K, Monteleone AM, Monteleone P, Nacmias B, Navratilova M, Ntalla I, O'Toole JK, Ophoff RA, Padyukov L, Palotie A, Pantel J, Papezova H, Pinto D, Rabionet R, Raevuori A, Ramoz N, Reichborn-Kjennerud T, Ricca V, Ripatti S, Ritschel F, Roberts M, Rotondo A, Rujescu D, Rybakowski F, Santonastaso P, Scherag A, Scherer SW, Schmidt U, Schork NJ, Schosser A, Seitz J, Slachtova L, Slagboom PE, Slof-Op't Landt MCT, Slopien A, Sorbi S, Swiatkowska B, Szatkiewicz JP, Tachmazidou I, Tenconi E, Tortorella A, Tozzi F, Treasure J, Tsitsika A, Tyszkiewicz-Nwafor M, Tziouvas K, van Elburg AA, van Furth EF, Wagner G, Walton E, Widen E, Zeggini E, Zerwas S, Zipfel S, Bergen AW, Boden JM, Brandt H, Crawford S, Halmi KA, Horwood LJ, Johnson C, Kaplan AS, Kaye WH, Mitchell J, Olsen CM, Pearson JF, Pedersen NL, Strober M, Werge T, Whiteman DC, Woodside DB, Grove J, Henders AK, Larsen JT, Parker R, Petersen LV, Jordan J, Kennedy MA, Birgegård A, Lichtenstein P, Norring C, Landén M, Mortensen PB, Polimanti R, McClintick JN, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Degenhardt F, Docherty AR, Edwards AC, Foo JC, Fox L, Frank J, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Hodgkinson C, Hoffmann P, Hottenga JJ, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Peterson RE, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, Zhou H, Boardman JD, Chen D, Choi DS, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Frye MA, Gäebel W, Hayward C, Ising M, Keyes M, Kiefer F, Koller G, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray AD, Nurnberger JI, Preuss U, Räikkönen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt SH, Wodarz N, Zill P, Adkins DE, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Costello EJ, de Wit H, Diazgranados N, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Hesselbrock V, Hewitt JK, Hopfer CJ, Iacono WG, Johnson EO, Karpyak VM, Kendler KS, Kranzler HR, Krauter K, Lind PA, McGue M, MacKillop J, Madden PAF, Maes HH, Magnusson PKE, Nelson EC, Nöthen MM, Palmer AA, Penninx BWJH, Porjesz B, Rice JP, Rietschel M, Riley BP, Rose RJ, Shen PH, Silberg J, Stallings MC, Tarter RE, Vanyukov MM, Vrieze S, Wall TL, Whitfield JB, Zhao H, Neale BM, Wade TD, et al. Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addict Biol. 2020 Feb 16; e12880. View in: PubMed

  5. Bershad AK, Preller KH, Lee R, Keedy S, Wren-Jarvis J, Bremmer MP, de Wit H. Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Apr; 5(4):461-467. View in: PubMed

  6. Weafer J, Phan KL, de Wit H. Poor inhibitory control is associated with greater stimulation and less sedation following alcohol. Psychopharmacology (Berl). 2020 Mar; 237(3):825-832. View in: PubMed

  7. Meyre D, Mohamed S, Gray JC, Weafer J, MacKillop J, de Wit H. Association between impulsivity traits and body mass index at the observational and genetic epidemiology level. Sci Rep. 2019 11 26; 9(1):17583. View in: PubMed

  8. Langenecker SA, Kling LR, Crane NA, Gorka SM, Nusslock R, Damme KSF, Weafer J, de Wit H, Phan KL. Anticipation of monetary reward in amygdala, insula, caudate are predictors of pleasure sensitivity to d-Amphetamine administration. Drug Alcohol Depend. 2020 01 01; 206:107725. View in: PubMed

  9. Doss MK, Weafer J, Gallo DA, de Wit H. ?9-Tetrahydrocannabinol During Encoding Impairs Perceptual Details yet Spares Context Effects on Episodic Memory. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 01; 5(1):110-118. View in: PubMed

  10. Pabon E, de Wit H. Developing a phone-based measure of impairment after acute oral ?9-tetrahydrocannabinol. J Psychopharmacol. 2019 09; 33(9):1160-1169. View in: PubMed

  11. de Wit H, Bershad AK. MDMA enhances pleasantness of affective touch. Neuropsychopharmacology. 2020 01; 45(1):217-239. View in: PubMed

  12. Bershad AK, Schepers ST, Bremmer MP, Lee R, de Wit H. Acute Subjective and Behavioral Effects of Microdoses of Lysergic Acid Diethylamide in Healthy Human Volunteers. Biol Psychiatry. 2019 11 15; 86(10):792-800. View in: PubMed

  13. Schepers ST, Arndt DL, Rogers RD, Hedeker D, de Wit H. Subjective responses to amphetamine in young adults with previous mood elevation experiences. Psychopharmacology (Berl). 2019 Nov; 236(11):3363-3370. View in: PubMed

  14. Cryan JF, de Wit H. The gut microbiome in psychopharmacology and psychiatry. Psychopharmacology (Berl). 2019 05; 236(5):1407-1409. View in: PubMed

  15. Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL. Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability. Nat Neurosci. 2019 Jul; 22(7):1196. View in: PubMed

  16. Weafer J, Van Hedger K, Keedy SK, Nwaokolo N, de Wit H. Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults. Addict Biol. 2020 May; 25(3):e12775. View in: PubMed

  17. Bershad AK, Mayo LM, Van Hedger K, McGlone F, Walker SC, de Wit H. Effects of MDMA on attention to positive social cues and pleasantness of affective touch. Neuropsychopharmacology. 2019 09; 44(10):1698-1705. View in: PubMed

  18. Pabon E, MacKillop J, Palmer AA, de Wit H. Multidimensional latent structure of risk-related phenotypes in healthy young adults. Exp Clin Psychopharmacol. 2020 Feb; 28(1):55-64. View in: PubMed

  19. Weafer J, Crane NA, Gorka SM, Phan KL, de Wit H. Neural correlates of inhibition and reward are negatively associated. Neuroimage. 2019 08 01; 196:188-194. View in: PubMed

  20. Gray JC, Sanchez-Roige S, de Wit H, MacKillop J, Palmer AA. Genomic basis of delayed reward discounting. Behav Processes. 2019 May; 162:157-161. View in: PubMed

  21. Sanchez-Roige S, Fontanillas P, Elson SL, Gray JC, de Wit H, MacKillop J, Palmer AA. Genome-Wide Association Studies of Impulsive Personality Traits (BIS-11 and UPPS-P) and Drug Experimentation in up to 22,861 Adult Research Participants Identify Loci in the CACNA1I and CADM2 genes. J Neurosci. 2019 03 27; 39(13):2562-2572. View in: PubMed

  22. Sanchez-Roige S, Fontanillas P, Elson SL. Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. Nat Neurosci. 2019 Mar; 22(3):503. View in: PubMed

  23. Van Hedger K, Keedy SK, Schertz KE, Berman MG, de Wit H. Effects of methamphetamine on neural responses to visual stimuli. Psychopharmacology (Berl). 2019 Jun; 236(6):1741-1748. View in: PubMed

  24. Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Chou YL, Degenhardt F, Docherty AR, Edwards AC, Fontanillas P, Foo JC, Fox L, Frank J, Giegling I, Gordon S, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Herms S, Hodgkinson C, Hoffmann P, Jan Hottenga J, Kennedy MA, Alanne-Kinnunen M, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Pearson JF, Peterson RE, Ripatti S, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG. Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci. 2018 12; 21(12):1656-1669. View in: PubMed

  25. MacKillop J, Gray JC, Weafer J, Sanchez-Roige S, Palmer AA, de Wit H. Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach. Exp Clin Psychopharmacol. 2019 Feb; 27(1):29-37. View in: PubMed

  26. Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nat Neurosci. 2018 09; 21(9):1161-1170. View in: PubMed

  27. Weafer J, Ross TJ, O'Connor S, Stein EA, de Wit H, Childs E. Striatal activity correlates with stimulant-like effects of alcohol in healthy volunteers. Neuropsychopharmacology. 2018 12; 43(13):2532-2538. View in: PubMed

  28. Van Hedger K, Bershad AK, Lee R, de Wit H. Effects of Intranasal Oxytocin on Stress-Induced Cigarette Craving in Daily Smokers. Nicotine Tob Res. 2020 01 27; 22(1):89-95. View in: PubMed

  29. Doss MK, Weafer J, Ruiz NA, Gallo DA, De Wit H. Alcohol and pharmacologically similar sedatives impair encoding and facilitate consolidation of both recollection and familiarity in episodic memory. Cogn Neurosci. 2018 Jul - Oct; 9(3-4):89-99. View in: PubMed

  30. Vena A, King A, Lee R, de Wit H. Intranasal Oxytocin Does Not Modulate Responses to Alcohol in Social Drinkers. Alcohol Clin Exp Res. 2018 09; 42(9):1725-1734. View in: PubMed

  31. Doss MK, Weafer J, Gallo DA, de Wit H. ?9-Tetrahydrocannabinol at Retrieval Drives False Recollection of Neutral and Emotional Memories. Biol Psychiatry. 2018 11 15; 84(10):743-750. View in: PubMed

  32. de Wit H, Epstein DH, Preston KL. Does human language limit translatability of clinical and preclinical addiction research? Neuropsychopharmacology. 2018 09; 43(10):1985-1988. View in: PubMed

  33. Sanchez-Roige S, Fontanillas P, Elson SL. Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. Nat Neurosci. 2018 Jul; 21(7):1018. View in: PubMed

  34. Van Hedger K, Kushner MJ, Lee R, de Wit H. Oxytocin Reduces Cigarette Consumption in Daily Smokers. Nicotine Tob Res. 2019 05 21; 21(6):799-804. View in: PubMed

  35. Bershad AK, Miller MA, Norman GJ, de Wit H. Effects of opioid- and non-opioid analgesics on responses to psychosocial stress in humans. Horm Behav. 2018 06; 102:41-47. View in: PubMed

  36. Crane NA, Gorka SM, Weafer J, Langenecker SA, de Wit H, Phan KL. Neural activation to monetary reward is associated with amphetamine reward sensitivity. Neuropsychopharmacology. 2018 07; 43(8):1738-1744. View in: PubMed

  37. de Wit H, Sayette M. Considering the context: social factors in responses to drugs in humans. Psychopharmacology (Berl). 2018 04; 235(4):935-945. View in: PubMed

  38. Van Hedger K, Keedy SK, Mayo LM, Heilig M, de Wit H. Neural responses to cues paired with methamphetamine in healthy volunteers. Neuropsychopharmacology. 2018 07; 43(8):1732-1737. View in: PubMed

  39. Curran HV, Nutt D, de Wit H. Psychedelics and related drugs: therapeutic possibilities, mechanisms and regulation. Psychopharmacology (Berl). 2018 02; 235(2):373-375. View in: PubMed

  40. Sanchez-Roige S, Fontanillas P, Elson SL. Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. Nat Neurosci. 2018 01; 21(1):16-18. View in: PubMed

  41. Gray JC, MacKillop J, Weafer J, Hernandez KM, Gao J, Palmer AA, de Wit H. Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation. Psychiatry Res. 2018 01; 259:398-404. View in: PubMed

  42. Sanchez-Roige S, Fontanillas P, Elson SL. Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry. Addict Biol. 2019 01; 24(1):121-131. View in: PubMed

  43. Bershad AK, Ruiz NA, de Wit H. Effects of Buprenorphine on Responses to Emotional Stimuli in Individuals with a Range of Mood Symptomatology. Int J Neuropsychopharmacol. 2018 02 01; 21(2):120-127. View in: PubMed

  44. Crane NA, Gorka SM, Weafer J, Langenecker SA, de Wit H, Phan KL. Preliminary Evidence for Disrupted Nucleus Accumbens Reactivity and Connectivity to Reward in Binge Drinkers. Alcohol Alcohol. 2017 Nov 01; 52(6):647-654. View in: PubMed

  45. Palmisano AN, Hudd EC, McQuade CM, de Wit H, Astur RS. The effects of nicotine on conditioning, extinction, and reinstatement in humans. Addict Behav. 2018 Feb; 77:51-58. View in: PubMed

  46. Arndt DL, de Wit H. Cannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults. Cannabis Cannabinoid Res. 2017; 2(1):105-113. View in: PubMed

  47. Van Hedger K, Bershad AK, de Wit H. Pharmacological challenge studies with acute psychosocial stress. Psychoneuroendocrinology. 2017 Nov; 85:123-133. View in: PubMed

  48. Doss MK, Weafer J, Gallo DA, de Wit H. MDMA Impairs Both the Encoding and Retrieval of Emotional Recollections. Neuropsychopharmacology. 2018 03; 43(4):791-800. View in: PubMed

  49. Weafer J, Lyon N, Hedeker D, de Wit H. Sweet taste liking is associated with subjective response to amphetamine in women but not men. Psychopharmacology (Berl). 2017 Nov; 234(21):3185-3194. View in: PubMed

  50. Childs E, Lutz JA, de Wit H. Dose-related effects of delta-9-THC on emotional responses to acute psychosocial stress. Drug Alcohol Depend. 2017 08 01; 177:136-144. View in: PubMed

  51. Bidwell LC, Gray JC, Weafer J, Palmer AA, de Wit H, MacKillop J. Genetic influences on ADHD symptom dimensions: Examination of a priori candidates, gene-based tests, genome-wide variation, and SNP heritability. Am J Med Genet B Neuropsychiatr Genet. 2017 Jun; 174(4):458-466. View in: PubMed

  52. Bershad AK, Miller MA, de Wit H. MDMA does not alter responses to the Trier Social Stress Test in humans. Psychopharmacology (Berl). 2017 Jul; 234(14):2159-2166. View in: PubMed

  53. Cryan JF, de Wit H. Special issue: recognizing the lifetime scientific contributions of Athina Markou. Psychopharmacology (Berl). 2017 05; 234(9-10):1311-1313. View in: PubMed

  54. Weafer J, Gorka SM, Hedeker D, Dzemidzic M, Kareken DA, Phan KL, de Wit H. Associations Between Behavioral and Neural Correlates of Inhibitory Control and Amphetamine Reward Sensitivity. Neuropsychopharmacology. 2017 Aug; 42(9):1905-1913. View in: PubMed

  55. Childs E, Astur RS, de Wit H. Virtual reality conditioned place preference using monetary reward. Behav Brain Res. 2017 03 30; 322(Pt A):110-114. View in: PubMed

  56. Miller MA, Bershad A, King AC, Lee R, de Wit H. Intranasal oxytocin dampens cue-elicited cigarette craving in daily smokers: a pilot study. Behav Pharmacol. 2016 12; 27(8):697-703. View in: PubMed

  57. Francis SM, Kirkpatrick MG, de Wit H, Jacob S. Urinary and plasma oxytocin changes in response to MDMA or intranasal oxytocin administration. Psychoneuroendocrinology. 2016 12; 74:92-100. View in: PubMed

  58. Bershad AK, Miller MA, Baggott MJ, de Wit H. The effects of MDMA on socio-emotional processing: Does MDMA differ from other stimulants? J Psychopharmacol. 2016 12; 30(12):1248-1258. View in: PubMed

  59. Cavallo JS, Mayo LM, de Wit H. Acquisition of Conditioning between Methamphetamine and Cues in Healthy Humans. PLoS One. 2016; 11(8):e0161541. View in: PubMed

  60. MacKillop J, Weafer J, C Gray J, Oshri A, Palmer A, de Wit H. The latent structure of impulsivity: impulsive choice, impulsive action, and impulsive personality traits. Psychopharmacology (Berl). 2016 Sep; 233(18):3361-70. View in: PubMed

  61. Childs E, de Wit H. Alcohol-induced place conditioning in moderate social drinkers. Addiction. 2016 12; 111(12):2157-2165. View in: PubMed

  62. Shaham Y, de Wit H. Lost in Translation: CRF1 Receptor Antagonists and Addiction Treatment. Neuropsychopharmacology. 2016 11; 41(12):2795-2797. View in: PubMed

  63. Childs E, Bershad AK, de Wit H. Effects of d-amphetamine upon psychosocial stress responses. J Psychopharmacol. 2016 07; 30(7):608-15. View in: PubMed

  64. Cavallo JS, Ruiz NA, de Wit H. Extinction of Conditioned Responses to Methamphetamine-Associated Stimuli in Healthy Humans. Psychopharmacology (Berl). 2016 07; 233(13):2489-502. View in: PubMed

  65. Mayo LM, de Wit H. Acquisition of Conditioned Responses to a Novel Alcohol-Paired Cue in Social Drinkers. J Stud Alcohol Drugs. 2016 Mar; 77(2):317-26. View in: PubMed

  66. Steckler T, Curran HV, de Wit H, Howes O, Hoyer D, Lucki I, Miczek KA, Morrow AL, Price LH, Robbins TW. Editorial: Reporting guidelines for psychopharmacology. Psychopharmacology (Berl). 2016 Apr; 233(7):1131-4. View in: PubMed

  67. Smith CT, Weafer J, Cowan RL, Kessler RM, Palmer AA, de Wit H, Zald DH. Individual differences in timing of peak positive subjective responses to d-amphetamine: Relationship to pharmacokinetics and physiology. J Psychopharmacol. 2016 Apr; 30(4):330-43. View in: PubMed

  68. Bershad AK, Weafer JJ, Kirkpatrick MG, Wardle MC, Miller MA, de Wit H. Oxytocin receptor gene variation predicts subjective responses to MDMA. Soc Neurosci. 2016 12; 11(6):592-9. View in: PubMed

  69. Weafer J, Gallo DA, de Wit H. Acute Effects of Alcohol on Encoding and Consolidation of Memory for Emotional Stimuli. J Stud Alcohol Drugs. 2016 Jan; 77(1):86-94. View in: PubMed

  70. Wardle MC, Bershad AK, de Wit H. Naltrexone alters the processing of social and emotional stimuli in healthy adults. Soc Neurosci. 2016 12; 11(6):579-91. View in: PubMed

  71. Temple JL, Ziegler AM, Martin C, de Wit H. Subjective Responses to Caffeine Are Influenced by Caffeine Dose, Sex, and Pubertal Stage. J Caffeine Res. 2015 Dec 01; 5(4):167-175. View in: PubMed

  72. Wardle MC, Marcus BA, de Wit H. A Preliminary Investigation of Individual Differences in Subjective Responses to D-Amphetamine, Alcohol, and Delta-9-Tetrahydrocannabinol Using a Within-Subjects Randomized Trial. PLoS One. 2015; 10(10):e0140501. View in: PubMed

  73. Kirkpatrick MG, Goldenson NI, Kapadia N, Kahler CW, de Wit H, Swift RM, McGeary JE, Sussman S, Leventhal AM. Emotional traits predict individual differences in amphetamine-induced positive mood in healthy volunteers. Psychopharmacology (Berl). 2016 Jan; 233(1):89-97. View in: PubMed

  74. Bershad AK, Seiden JA, de Wit H. Effects of buprenorphine on responses to social stimuli in healthy adults. Psychoneuroendocrinology. 2016 Jan; 63:43-9. View in: PubMed

  75. VanderBroek L, Acker J, Palmer AA, de Wit H, MacKillop J. Interrelationships among parental family history of substance misuse, delay discounting, and personal substance use. Psychopharmacology (Berl). 2016 Jan; 233(1):39-48. View in: PubMed

  76. de Wit H, Gorka SM, Phan KL. The Ups and Downs of 3,4-Methylenedioxymethamphetamine: Linking Subjective Effects to Spontaneous Brain Function. Biol Psychiatry. 2015 Oct 15; 78(8):519-21. View in: PubMed

  77. van den Berg SM, de Moor MH, Verweij KJ, Krueger RF, Luciano M, Arias Vasquez A, Matteson LK, Derringer J, Esko T, Amin N, Gordon SD, Hansell NK, Hart AB, Seppälä I, Huffman JE, Konte B, Lahti J, Lee M, Miller M, Nutile T, Tanaka T, Teumer A, Viktorin A, Wedenoja J, Abdellaoui A, Abecasis GR, Adkins DE, Agrawal A, Allik J, Appel K, Bigdeli TB, Busonero F, Campbell H, Costa PT, Smith GD, Davies G, de Wit H, Ding J, Engelhardt BE, Eriksson JG, Fedko IO, Ferrucci L, Franke B, Giegling I, Grucza R, Hartmann AM, Heath AC, Heinonen K, Henders AK, Homuth G, Hottenga JJ, Iacono WG, Janzing J, Jokela M, Karlsson R, Kemp JP, Kirkpatrick MG, Latvala A, Lehtimäki T, Liewald DC, Madden PA, Magri C, Magnusson PK, Marten J, Maschio A, Mbarek H, Medland SE, Mihailov E, Milaneschi Y, Montgomery GW, Nauck M, Nivard MG, Ouwens KG, Palotie A, Pettersson E, Polasek O, Qian Y, Pulkki-Råback L, Raitakari OT, Realo A, Rose RJ, Ruggiero D, Schmidt CO, Slutske WS, Sorice R, Starr JM, St Pourcain B, Sutin AR, Timpson NJ, Trochet H, Vermeulen S, Vuoksimaa E, Widen E, Wouda J, Wright MJ, Zgaga L. Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. Behav Genet. 2016 Mar; 46(2):170-82. View in: PubMed

  78. de Wit HM, Engwerda EE, Tack CJ, de Galan BE. Insulin administered by needle-free jet injection corrects marked hyperglycaemia faster in overweight or obese patients with diabetes. Diabetes Obes Metab. 2015 Nov; 17(11):1093-9. View in: PubMed

  79. Miller MA, Bershad AK, de Wit H. Drug effects on responses to emotional facial expressions: recent findings. Behav Pharmacol. 2015 Sep; 26(6):571-9. View in: PubMed

  80. Weafer J, De Arcangelis J, de Wit H. Sex differences in behavioral impulsivity in at-risk and non-risk drinkers. Front Psychiatry. 2015; 6:72. View in: PubMed

  81. Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. JAMA Psychiatry. 2015 Jul; 72(7):642-50. View in: PubMed

  82. Baggott MJ, Kirkpatrick MG, Bedi G, de Wit H. Intimate insight: MDMA changes how people talk about significant others. J Psychopharmacol. 2015 Jun; 29(6):669-77. View in: PubMed

  83. Bershad AK, Kirkpatrick MG, Seiden JA, de Wit H. Effects of acute doses of prosocial drugs methamphetamine and alcohol on plasma oxytocin levels. J Clin Psychopharmacol. 2015 Jun; 35(3):308-12. View in: PubMed

  84. Yarosh HL, Meda SA, de Wit H, Hart AB, Pearlson GD. Multivariate analysis of subjective responses to d-amphetamine in healthy volunteers finds novel genetic pathway associations. Psychopharmacology (Berl). 2015 Aug; 232(15):2781-94. View in: PubMed

  85. Kirkpatrick M, Delton AW, Robertson TE, de Wit H. Prosocial effects of MDMA: A measure of generosity. J Psychopharmacol. 2015 Jun; 29(6):661-8. View in: PubMed

  86. Ballard ME, Weafer J, Gallo DA, de Wit H. Effects of acute methamphetamine on emotional memory formation in humans: encoding vs consolidation. PLoS One. 2015; 10(2):e0117062. View in: PubMed

  87. Mayo LM, de Wit H. Acquisition of responses to a methamphetamine-associated cue in healthy humans: self-report, behavioral, and psychophysiological measures. Neuropsychopharmacology. 2015 Jun; 40(7):1734-41. View in: PubMed

  88. Gorka SM, Fitzgerald DA, de Wit H, Phan KL. Cannabinoid modulation of amygdala subregion functional connectivity to social signals of threat. Int J Neuropsychopharmacol. 2014 Dec 28; 18(3). View in: PubMed

  89. Bershad AK, Jaffe JH, Childs E, de Wit H. Opioid partial agonist buprenorphine dampens responses to psychosocial stress in humans. Psychoneuroendocrinology. 2015 Feb; 52:281-8. View in: PubMed

  90. Hanlon EC, Tasali E, Leproult R, Stuhr KL, Doncheck E, de Wit H, Hillard CJ, Van Cauter E. Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol. J Clin Endocrinol Metab. 2015 Jan; 100(1):220-6. View in: PubMed

  91. Kirkpatrick MG, de Wit H. MDMA: a social drug in a social context. Psychopharmacology (Berl). 2015 Mar; 232(6):1155-63. View in: PubMed

  92. Gorka SM, Fitzgerald DA, de Wit H, Angstadt M, Phan KL. Opioid modulation of resting-state anterior cingulate cortex functional connectivity. J Psychopharmacol. 2014 Dec; 28(12):1115-24. View in: PubMed

  93. Childs E, White TL, de Wit H. Personality traits modulate emotional and physiological responses to stress. Behav Pharmacol. 2014 Sep; 25(5-6):493-502. View in: PubMed

  94. Weafer J, Burkhardt A, de Wit H. Sweet taste liking is associated with impulsive behaviors in humans. Front Behav Neurosci. 2014; 8:228. View in: PubMed

  95. Kirkpatrick MG, Francis SM, Lee R, de Wit H, Jacob S. Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans. Psychoneuroendocrinology. 2014 Aug; 46:23-31. View in: PubMed

  96. Childs E, de Wit H. Regular exercise is associated with emotional resilience to acute stress in healthy adults. Front Physiol. 2014; 5:161. View in: PubMed

  97. Wardle MC, Fitzgerald DA, Angstadt M, Rabinak CA, de Wit H, Phan KL. Effects of oxycodone on brain responses to emotional images. Psychopharmacology (Berl). 2014 Nov; 231(22):4403-15. View in: PubMed

  98. Wardle MC, de Wit H. MDMA alters emotional processing and facilitates positive social interaction. Psychopharmacology (Berl). 2014 Oct; 231(21):4219-29. View in: PubMed

  99. Hart AB, Gamazon ER, Engelhardt BE, Sklar P, Kähler AK, Hultman CM, Sullivan PF, Neale BM, Faraone SV. Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5968-73. View in: PubMed

  100. Bedi G, Cecchi GA, Slezak DF, Carrillo F, Sigman M, de Wit H. A window into the intoxicated mind? Speech as an index of psychoactive drug effects. Neuropsychopharmacology. 2014 Sep; 39(10):2340-8. View in: PubMed

  101. Wardle MC, Kirkpatrick MG, de Wit H. 'Ecstasy' as a social drug: MDMA preferentially affects responses to emotional stimuli with social content. Soc Cogn Affect Neurosci. 2014 Aug; 9(8):1076-81. View in: PubMed

  102. Kirkpatrick MG, Baggott MJ, Mendelson JE, Galloway GP, Liechti ME, Hysek CM, de Wit H. MDMA effects consistent across laboratories. Psychopharmacology (Berl). 2014 Oct; 231(19):3899-905. View in: PubMed

  103. Clark DB, de Wit H, Iacono WG. ADHD, impulsivity and alcohol abuse: methods, results, and implications. Exp Clin Psychopharmacol. 2014 Apr; 22(2):141-3. View in: PubMed

  104. de Wit H, Hoek JB. Farewell to Drs. Ivan Diamond and T.-K. Li. Alcohol Clin Exp Res. 2014 Jul; 38(7):1821. View in: PubMed

  105. Weafer J, Gallo DA, de Wit H. Amphetamine fails to alter cued recollection of emotional images: study of encoding, retrieval, and state-dependency. PLoS One. 2014; 9(2):e90423. View in: PubMed

  106. Kirkpatrick MG, Lee R, Wardle MC, Jacob S, de Wit H. Effects of MDMA and Intranasal oxytocin on social and emotional processing. Neuropsychopharmacology. 2014 Jun; 39(7):1654-63. View in: PubMed

  107. Frye CG, Wardle MC, Norman GJ, de Wit H. MDMA decreases the effects of simulated social rejection. Pharmacol Biochem Behav. 2014 Feb; 117:1-6. View in: PubMed

  108. Weafer J, de Wit H. Sex differences in impulsive action and impulsive choice. Addict Behav. 2014 Nov; 39(11):1573-1579. View in: PubMed

  109. Ballard ME, Gallo DA, de Wit H. Amphetamine increases errors during episodic memory retrieval. J Clin Psychopharmacol. 2014 Feb; 34(1):85-92. View in: PubMed

  110. Weafer J, Baggott MJ, de Wit H. Test-retest reliability of behavioral measures of impulsive choice, impulsive action, and inattention. Exp Clin Psychopharmacol. 2013 Dec; 21(6):475-81. View in: PubMed

  111. Weafer J, de Wit H. Inattention, impulsive action, and subjective response to D-amphetamine. Drug Alcohol Depend. 2013 Nov 01; 133(1):127-33. View in: PubMed

  112. Heinz AJ, de Wit H, Lilje TC, Kassel JD. The combined effects of alcohol, caffeine, and expectancies on subjective experience, impulsivity, and risk-taking. Exp Clin Psychopharmacol. 2013 Jun; 21(3):222-34. View in: PubMed

  113. Kirkpatrick MG, de Wit H. In the company of others: social factors alter acute alcohol effects. Psychopharmacology (Berl). 2013 Nov; 230(2):215-26. View in: PubMed

  114. Napier TC, Herrold AA, de Wit H. Using conditioned place preference to identify relapse prevention medications. Neurosci Biobehav Rev. 2013 Nov; 37(9 Pt A):2081-6. View in: PubMed

  115. Baggott MJ, Childs E, Hart AB, de Bruin E, Palmer AA, Wilkinson JE, de Wit H. Psychopharmacology of theobromine in healthy volunteers. Psychopharmacology (Berl). 2013 Jul; 228(1):109-18. View in: PubMed

  116. Mayo LM, Fraser D, Childs E, Momenan R, Hommer DW, de Wit H, Heilig M. Conditioned preference to a methamphetamine-associated contextual cue in humans. Neuropsychopharmacology. 2013 May; 38(6):921-9. View in: PubMed

  117. Kirkpatrick MG, Johanson CE, de Wit H. Personality and the acute subjective effects of d-amphetamine in humans. J Psychopharmacol. 2013 Mar; 27(3):256-64. View in: PubMed

  118. Wardle MC, de Wit H, Penton-Voak I, Lewis G, Munafò MR. Lack of association between COMT and working memory in a population-based cohort of healthy young adults. Neuropsychopharmacology. 2013 Jun; 38(7):1253-63. View in: PubMed

  119. Zorrilla EP, Heilig M, de Wit H, Shaham Y. Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. Drug Alcohol Depend. 2013 Mar 01; 128(3):175-86. View in: PubMed

  120. Conrad M, Wardle M, King A, de Wit H. Relationship of self-reported and acute stress to smoking in emerging adult smokers. J Clin Psychol. 2013 Jul; 69(7):710-7. View in: PubMed

  121. Morean ME, de Wit H, King AC, Sofuoglu M, Rueger SY, O'Malley SS. The drug effects questionnaire: psychometric support across three drug types. Psychopharmacology (Berl). 2013 May; 227(1):177-92. View in: PubMed

  122. Wardle MC, Hart AB, Palmer AA, de Wit H. Does COMT genotype influence the effects of d-amphetamine on executive functioning? Genes Brain Behav. 2013 Feb; 12(1):13-20. View in: PubMed

  123. Ballard ME, Gallo DA, de Wit H. Pre-encoding administration of amphetamine or THC preferentially modulates emotional memory in humans. Psychopharmacology (Berl). 2013 Apr; 226(3):515-29. View in: PubMed

  124. Heinz AJ, Lilje TC, Kassel JD, de Wit H. Quantifying reinforcement value and demand for psychoactive substances in humans. Curr Drug Abuse Rev. 2012 Dec; 5(4):257-72. View in: PubMed

  125. Hart AB, Engelhardt BE, Wardle MC, Sokoloff G, Stephens M, de Wit H, Palmer AA. Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). PLoS One. 2012; 7(8):e42646. View in: PubMed

  126. Dlugos A, Childs E, Stuhr KL, Hillard CJ, de Wit H. Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans. Neuropsychopharmacology. 2012 Oct; 37(11):2416-27. View in: PubMed

  127. Wardle MC, Treadway MT, de Wit H. Caffeine increases psychomotor performance on the effort expenditure for rewards task. Pharmacol Biochem Behav. 2012 Oct; 102(4):526-31. View in: PubMed

  128. Metrik J, Kahler CW, Reynolds B, McGeary JE, Monti PM, Haney M, de Wit H, Rohsenow DJ. Balanced placebo design with marijuana: pharmacological and expectancy effects on impulsivity and risk taking. Psychopharmacology (Berl). 2012 Oct; 223(4):489-99. View in: PubMed

  129. Ballard ME, Bedi G, de Wit H. Effects of delta-9-tetrahydrocannabinol on evaluation of emotional images. J Psychopharmacol. 2012 Oct; 26(10):1289-98. View in: PubMed

  130. de Wit H, Phillips TJ. Do initial responses to drugs predict future use or abuse? Neurosci Biobehav Rev. 2012 Jul; 36(6):1565-76. View in: PubMed

  131. Yip SW, Doherty J, Wakeley J, Saunders K, Tzagarakis C, de Wit H, Goodwin GM, Rogers RD. Reduced subjective response to acute ethanol administration among young men with a broad bipolar phenotype. Neuropsychopharmacology. 2012 Jul; 37(8):1808-15. View in: PubMed

  132. Childs E, Roche DJ, King AC, de Wit H. Varenicline potentiates alcohol-induced negative subjective responses and offsets impaired eye movements. Alcohol Clin Exp Res. 2012 May; 36(5):906-14. View in: PubMed

  133. Hart AB, de Wit H, Palmer AA. Genetic factors modulating the response to stimulant drugs in humans. Curr Top Behav Neurosci. 2012; 12:537-77. View in: PubMed

  134. Palmer AA, de Wit H. Translational genetic approaches to substance use disorders: bridging the gap between mice and humans. Hum Genet. 2012 Jun; 131(6):931-9. View in: PubMed

  135. Rabinak CA, Sripada CS, Angstadt M, de Wit H, Phan KL. Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect. J Neural Transm (Vienna). 2012 Jun; 119(6):701-7. View in: PubMed

  136. Childs E, de Wit H. Contextual conditioning enhances the psychostimulant and incentive properties of d-amphetamine in humans. Addict Biol. 2013 Nov; 18(6):985-92. View in: PubMed

  137. Wardle MC, Treadway MT, Mayo LM, Zald DH, de Wit H. Amping up effort: effects of d-amphetamine on human effort-based decision-making. J Neurosci. 2011 Nov 16; 31(46):16597-602. View in: PubMed

  138. Wardle MC, de Wit H. Effects of amphetamine on reactivity to emotional stimuli. Psychopharmacology (Berl). 2012 Mar; 220(1):143-53. View in: PubMed

  139. de Wit H. Sex hormones: a new treatment for cocaine abuse? Neuropsychopharmacology. 2011 Oct; 36(11):2155-6. View in: PubMed

  140. Wardle MC, Yang A, de Wit H. Effect of d-amphetamine on post-error slowing in healthy volunteers. Psychopharmacology (Berl). 2012 Mar; 220(1):109-15. View in: PubMed

  141. Childs E, O'Connor S, de Wit H. Bidirectional interactions between acute psychosocial stress and acute intravenous alcohol in healthy men. Alcohol Clin Exp Res. 2011 Oct; 35(10):1794-803. View in: PubMed

  142. Ballard ME, Gallo DA, de Wit H. Psychoactive drugs and false memory: comparison of dextroamphetamine and d-9-tetrahydrocannabinol on false recognition. Psychopharmacology (Berl). 2012 Jan; 219(1):15-24. View in: PubMed

  143. Wignall ND, de Wit H. Effects of nicotine on attention and inhibitory control in healthy nonsmokers. Exp Clin Psychopharmacol. 2011 Jun; 19(3):183-91. View in: PubMed

  144. King AC, de Wit H, McNamara PJ, Cao D. Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking. Arch Gen Psychiatry. 2011 Apr; 68(4):389-99. View in: PubMed

  145. Wardle M, Cederbaum K, de Wit H. Quantifying talk: developing reliable measures of verbal productivity. Behav Res Methods. 2011 Mar; 43(1):168-78. View in: PubMed

  146. Wardle MC, Munafò MR, de Wit H. Effect of social stress during acute nicotine abstinence. Psychopharmacology (Berl). 2011 Nov; 218(1):39-48. View in: PubMed

  147. Ballard ME, de Wit H. Combined effects of acute, very-low-dose ethanol and delta(9)-tetrahydrocannabinol in healthy human volunteers. Pharmacol Biochem Behav. 2011 Feb; 97(4):627-31. View in: PubMed

  148. Mahler SV, de Wit H. Cue-reactors: individual differences in cue-induced craving after food or smoking abstinence. PLoS One. 2010 Nov 10; 5(11):e15475. View in: PubMed

  149. Bedi G, Hyman D, de Wit H. Is ecstasy an "empathogen"? Effects of ±3,4-methylenedioxymethamphetamine on prosocial feelings and identification of emotional states in others. Biol Psychiatry. 2010 Dec 15; 68(12):1134-40. View in: PubMed

  150. Bedi G, Preston KL, Epstein DH, Heishman SJ, Marrone GF, Shaham Y, de Wit H. Incubation of cue-induced cigarette craving during abstinence in human smokers. Biol Psychiatry. 2011 Apr 01; 69(7):708-11. View in: PubMed

  151. Yang A, Childs E, Palmer AA, de Wit H. More on ADORA. Psychopharmacology (Berl). 2010 Dec; 212(4):699-700. View in: PubMed

  152. Comer SD, Bickel WK, Yi R, de Wit H, Higgins ST, Wenger GR, Johanson CE, Kreek MJ. Human behavioral pharmacology, past, present, and future: symposium presented at the 50th annual meeting of the Behavioral Pharmacology Society. Behav Pharmacol. 2010 Jul; 21(4):251-77. View in: PubMed

  153. Vaughn LK, Denning G, Stuhr KL, de Wit H, Hill MN, Hillard CJ. Endocannabinoid signalling: has it got rhythm? Br J Pharmacol. 2010 Jun; 160(3):530-43. View in: PubMed

  154. Yang A, Palmer AA, de Wit H. Genetics of caffeine consumption and responses to caffeine. Psychopharmacology (Berl). 2010 Aug; 211(3):245-57. View in: PubMed

  155. Lejuez CW, Magidson JF, Mitchell SH, Sinha R, Stevens MC, de Wit H. Behavioral and biological indicators of impulsivity in the development of alcohol use, problems, and disorders. Alcohol Clin Exp Res. 2010 Aug; 34(8):1334-45. View in: PubMed

  156. Hamidovic A, Dlugos A, Palmer AA, de Wit H. Catechol-O-methyltransferase val158met genotype modulates sustained attention in both the drug-free state and in response to amphetamine. Psychiatr Genet. 2010 Jun; 20(3):85-92. View in: PubMed

  157. Hamidovic A, Childs E, Conrad M, King A, de Wit H. Stress-induced changes in mood and cortisol release predict mood effects of amphetamine. Drug Alcohol Depend. 2010 Jun 01; 109(1-3):175-80. View in: PubMed

  158. Childs E, Van Dam NT, de Wit H. Effects of acute progesterone administration upon responses to acute psychosocial stress in men. Exp Clin Psychopharmacol. 2010 Feb; 18(1):78-86. View in: PubMed

  159. Hamidovic A, Dlugos A, Palmer AA, de Wit H. Polymorphisms in dopamine transporter (SLC6A3) are associated with stimulant effects of D-amphetamine: an exploratory pharmacogenetic study using healthy volunteers. Behav Genet. 2010 Mar; 40(2):255-61. View in: PubMed

  160. Childs E, Dlugos A, De Wit H. Cardiovascular, hormonal, and emotional responses to the TSST in relation to sex and menstrual cycle phase. Psychophysiology. 2010 May 01; 47(3):550-9. View in: PubMed

  161. Porcu P, O'Buckley TK, Alward SE, Song SC, Grant KA, de Wit H, Leslie Morrow A. Differential effects of ethanol on serum GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in mice, rats, cynomolgus monkeys, and humans. Alcohol Clin Exp Res. 2010 Mar 01; 34(3):432-42. View in: PubMed

  162. Hamidovic A, Dlugos A, Skol A, Palmer AA, de Wit H. Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants. Exp Clin Psychopharmacol. 2009 Dec; 17(6):374-83. View in: PubMed

  163. Dlugos AM, Hamidovic A, Hodgkinson CA, Goldman D, Palmer AA, de Wit H. More aroused, less fatigued: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine. Neuropsychopharmacology. 2010 Feb; 35(3):613-22. View in: PubMed

  164. Dlugos AM, Hamidovic A, Palmer AA, de Wit H. Further evidence of association between amphetamine response and SLC6A2 gene variants. Psychopharmacology (Berl). 2009 Oct; 206(3):501-11. View in: PubMed

  165. Bedi G, Phan KL, Angstadt M, de Wit H. Effects of MDMA on sociability and neural response to social threat and social reward. Psychopharmacology (Berl). 2009 Nov; 207(1):73-83. View in: PubMed

  166. Zacny JP, de Wit H. The prescription opioid, oxycodone, does not alter behavioral measures of impulsivity in healthy volunteers. Pharmacol Biochem Behav. 2009 Nov; 94(1):108-13. View in: PubMed

  167. Dlugos AM, Palmer AA, de Wit H. Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans. J Neural Transm (Vienna). 2009 Oct; 116(10):1323-34. View in: PubMed

  168. Metrik J, Rohsenow DJ, Monti PM, McGeary J, Cook TA, de Wit H, Haney M, Kahler CW. Effectiveness of a marijuana expectancy manipulation: Piloting the balanced-placebo design for marijuana. Exp Clin Psychopharmacol. 2009 Aug; 17(4):217-25. View in: PubMed

  169. de Wit H, Shaham Y. Incentive motivation, conditioning, stress, and neuropsychiatric disorders: a tribute to Jane Stewart. Biol Psychiatry. 2009 May 15; 65(10):827-8. View in: PubMed

  170. Hamidovic A, de Wit H. Sleep deprivation increases cigarette smoking. Pharmacol Biochem Behav. 2009 Sep; 93(3):263-9. View in: PubMed

  171. Childs E, de Wit H. Amphetamine-induced place preference in humans. Biol Psychiatry. 2009 May 15; 65(10):900-4. View in: PubMed

  172. White TL, Lejuez CW, de Wit H. Test-retest characteristics of the Balloon Analogue Risk Task (BART). Exp Clin Psychopharmacol. 2008 Dec; 16(6):565-70. View in: PubMed

  173. Childs E, de Wit H. Hormonal, cardiovascular, and subjective responses to acute stress in smokers. Psychopharmacology (Berl). 2009 Mar; 203(1):1-12. View in: PubMed

  174. de Wit H. Impulsivity as a determinant and consequence of drug use: a review of underlying processes. Addict Biol. 2009 Jan; 14(1):22-31. View in: PubMed

  175. Miczek KA, de Wit H. Challenges for translational psychopharmacology research--some basic principles. Psychopharmacology (Berl). 2008 Aug; 199(3):291-301. View in: PubMed

  176. Acheson A, de Wit H. Bupropion improves attention but does not affect impulsive behavior in healthy young adults. Exp Clin Psychopharmacol. 2008 Apr; 16(2):113-23. View in: PubMed

  177. Phan KL, Angstadt M, Golden J, Onyewuenyi I, Popovska A, de Wit H. Cannabinoid modulation of amygdala reactivity to social signals of threat in humans. J Neurosci. 2008 Mar 05; 28(10):2313-9. View in: PubMed

  178. Childs E, Hohoff C, Deckert J, Xu K, Badner J, de Wit H. Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology. 2008 Nov; 33(12):2791-800. View in: PubMed

  179. Childs E, de Wit H. Enhanced mood and psychomotor performance by a caffeine-containing energy capsule in fatigued individuals. Exp Clin Psychopharmacol. 2008 Feb; 16(1):13-21. View in: PubMed

  180. Hamidovic A, Kang UJ, de Wit H. Effects of low to moderate acute doses of pramipexole on impulsivity and cognition in healthy volunteers. J Clin Psychopharmacol. 2008 Feb; 28(1):45-51. View in: PubMed

  181. White TL, Lejuez CW, de Wit H. Personality and gender differences in effects of d-amphetamine on risk taking. Exp Clin Psychopharmacol. 2007 Dec; 15(6):599-609. View in: PubMed

  182. Acheson A, Richards JB, de Wit H. Effects of sleep deprivation on impulsive behaviors in men and women. Physiol Behav. 2007 Aug 15; 91(5):579-87. View in: PubMed

  183. Dlugos A, Freitag C, Hohoff C, McDonald J, Cook EH, Deckert J, de Wit H. Norepinephrine transporter gene variation modulates acute response to D-amphetamine. Biol Psychiatry. 2007 Jun 01; 61(11):1296-305. View in: PubMed

  184. Hariri AR, Brown SM, Williamson DE, Flory JD, de Wit H, Manuck SB. Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity. J Neurosci. 2006 Dec 20; 26(51):13213-7. View in: PubMed

  185. King A, de Wit H, Riley RC, Cao D, Niaura R, Hatsukami D. Efficacy of naltrexone in smoking cessation: a preliminary study and an examination of sex differences. Nicotine Tob Res. 2006 Oct; 8(5):671-82. View in: PubMed

  186. Lott DC, Kim SJ, Cook EH, de Wit H. Serotonin transporter genotype and acute subjective response to amphetamine. Am J Addict. 2006 Sep-Oct; 15(5):327-35. View in: PubMed

  187. White TL, Grover VK, de Wit H. Cortisol effects of D-amphetamine relate to traits of fearlessness and aggression but not anxiety in healthy humans. Pharmacol Biochem Behav. 2006 Sep; 85(1):123-31. View in: PubMed

  188. de Wit H, Vicini L, Childs E, Sayla MA, Terner J. Does stress reactivity or response to amphetamine predict smoking progression in young adults? A preliminary study. Pharmacol Biochem Behav. 2007 Feb; 86(2):312-9. View in: PubMed

  189. Acheson A, Farrar AM, Patak M, Hausknecht KA, Kieres AK, Choi S, de Wit H, Richards JB. Nucleus accumbens lesions decrease sensitivity to rapid changes in the delay to reinforcement. Behav Brain Res. 2006 Oct 16; 173(2):217-28. View in: PubMed

  190. Acheson A, Reynolds B, Richards JB, de Wit H. Diazepam impairs behavioral inhibition but not delay discounting or risk taking in healthy adults. Exp Clin Psychopharmacol. 2006 May; 14(2):190-8. View in: PubMed

  191. de Wit H, Vicini L, Haig GM, Hunt T, Feltner D. Evaluation of the abuse potential of pagoclone, a partial GABAA agonist. J Clin Psychopharmacol. 2006 Jun; 26(3):268-73. View in: PubMed

  192. Acheson A, Mahler SV, Chi H, de Wit H. Differential effects of nicotine on alcohol consumption in men and women. Psychopharmacology (Berl). 2006 May; 186(1):54-63. View in: PubMed

  193. Childs E, de Wit H. Subjective, behavioral, and physiological effects of acute caffeine in light, nondependent caffeine users. Psychopharmacology (Berl). 2006 May; 185(4):514-23. View in: PubMed

  194. Reynolds B, Richards JB, de Wit H. Acute-alcohol effects on the Experiential Discounting Task (EDT) and a question-based measure of delay discounting. Pharmacol Biochem Behav. 2006 Feb; 83(2):194-202. View in: PubMed

  195. Ramchandani VA, O'connor S, Neumark Y, Zimmermann US, Morzorati SL, de Wit H. The alcohol clamp: applications, challenges, and new directions--an RSA 2004 symposium summary. Alcohol Clin Exp Res. 2006 Jan; 30(1):155-64. View in: PubMed

  196. Terner JM, de Wit H. Menstrual cycle phase and responses to drugs of abuse in humans. Drug Alcohol Depend. 2006 Sep 01; 84(1):1-13. View in: PubMed

  197. King A, Munisamy G, de Wit H, Lin S. Attenuated cortisol response to alcohol in heavy social drinkers. Int J Psychophysiol. 2006 Mar; 59(3):203-9. View in: PubMed

  198. Holdstock L, Penland SN, Morrow AL, de Wit H. Moderate doses of ethanol fail to increase plasma levels of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one-like immunoreactivity in healthy men and women. Psychopharmacology (Berl). 2006 Jun; 186(3):442-50. View in: PubMed

  199. Veenstra-VanderWeele J, Qaadir A, Palmer AA, Cook EH, de Wit H. Association between the casein kinase 1 epsilon gene region and subjective response to D-amphetamine. Neuropsychopharmacology. 2006 May; 31(5):1056-63. View in: PubMed

  200. White TL, Lott DC, de Wit H. Personality and the subjective effects of acute amphetamine in healthy volunteers. Neuropsychopharmacology. 2006 May; 31(5):1064-74. View in: PubMed

  201. Alsene KM, Mahler SV, de Wit H. Effects of d-amphetamine and smoking abstinence on cue-induced cigarette craving. Exp Clin Psychopharmacol. 2005 Aug; 13(3):209-18. View in: PubMed

  202. Hohoff C, McDonald JM, Baune BT, Cook EH, Deckert J, de Wit H. Interindividual variation in anxiety response to amphetamine: possible role for adenosine A2A receptor gene variants. Am J Med Genet B Neuropsychiatr Genet. 2005 Nov 05; 139B(1):42-4. View in: PubMed

  203. Mahler SV, de Wit H. Effects of haloperidol on reactions to smoking cues in humans. Behav Pharmacol. 2005 Mar; 16(2):123-6. View in: PubMed

  204. Young EM, Mahler S, Chi H, de Wit H. Mecamylamine and ethanol preference in healthy volunteers. Alcohol Clin Exp Res. 2005 Jan; 29(1):58-65. View in: PubMed

  205. Lott DC, Kim SJ, Cook EH, de Wit H. Dopamine transporter gene associated with diminished subjective response to amphetamine. Neuropsychopharmacology. 2005 Mar; 30(3):602-9. View in: PubMed

  206. Reynolds B, Richards JB, Dassinger M, de Wit H. Therapeutic doses of diazepam do not alter impulsive behavior in humans. Pharmacol Biochem Behav. 2004 Sep; 79(1):17-24. View in: PubMed

  207. de Wit H, Richards JB. Dual determinants of drug use in humans: reward and impulsivity. Nebr Symp Motiv. 2004; 50:19-55. View in: PubMed

  208. Fromme K, de Wit H, Hutchison KE, Ray L, Corbin WR, Cook TA, Wall TL, Goldman D. Biological and behavioral markers of alcohol sensitivity. Alcohol Clin Exp Res. 2004 Feb; 28(2):247-56. View in: PubMed

  209. Zernig G, De Wit H, Telser S, Nienhusmeier M, Wakonigg G, Sturm K, Berger I, Kemmler G, Saria A. Subjective effects of slow-release bupropion versus caffeine as determined in a quasi-naturalistic setting. Pharmacology. 2004 Apr; 70(4):206-15. View in: PubMed

  210. Kieres AK, Hausknecht KA, Farrar AM, Acheson A, de Wit H, Richards JB. Effects of morphine and naltrexone on impulsive decision making in rats. Psychopharmacology (Berl). 2004 Apr; 173(1-2):167-74. View in: PubMed

  211. Farrar AM, Kieres AK, Hausknecht KA, de Wit H, Richards JB. Effects of reinforcer magnitude on an animal model of impulsive behavior. Behav Processes. 2003 Oct 31; 64(3):261-271. View in: PubMed

  212. de Wit H, Söderpalm AH, Nikolayev L, Young E. Effects of acute social stress on alcohol consumption in healthy subjects. Alcohol Clin Exp Res. 2003 Aug; 27(8):1270-7. View in: PubMed

  213. Söderpalm A, Nikolayev L, de Wit H. Effects of stress on responses to methamphetamine in humans. Psychopharmacology (Berl). 2003 Nov; 170(2):188-99. View in: PubMed

  214. Alsene K, Deckert J, Sand P, de Wit H. Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology. 2003 Sep; 28(9):1694-702. View in: PubMed

  215. McDonald J, Schleifer L, Richards JB, de Wit H. Effects of THC on behavioral measures of impulsivity in humans. Neuropsychopharmacology. 2003 Jul; 28(7):1356-65. View in: PubMed

  216. Chi H, de Wit H. Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkers. Alcohol Clin Exp Res. 2003 May; 27(5):780-6. View in: PubMed

  217. Alsene KM, Li Y, Chaverneff F, de Wit H. Role of abstinence and visual cues on food and smoking craving. Behav Pharmacol. 2003 Mar; 14(2):145-51. View in: PubMed

  218. de Wit H, Enggasser JL, Richards JB. Acute administration of d-amphetamine decreases impulsivity in healthy volunteers. Neuropsychopharmacology. 2002 Nov; 27(5):813-25. View in: PubMed

  219. Crean J, Richards JB, de Wit H. Effect of tryptophan depletion on impulsive behavior in men with or without a family history of alcoholism. Behav Brain Res. 2002 Nov 15; 136(2):349-57. View in: PubMed

  220. Shaham Y, Shalev U, Lu L, de Wit H, Stewart J. The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology (Berl). 2003 Jul; 168(1-2):3-20. View in: PubMed

  221. Reynolds B, de Wit H, Richards J. Delay of gratification and delay discounting in rats. Behav Processes. 2002 Sep 30; 59(3):157. View in: PubMed

  222. White TL, Justice AJ, de Wit H. Differential subjective effects of D-amphetamine by gender, hormone levels and menstrual cycle phase. Pharmacol Biochem Behav. 2002 Nov; 73(4):729-41. View in: PubMed

  223. Wachtel SR, Ortengren A, de Wit H. The effects of acute haloperidol or risperidone on subjective responses to methamphetamine in healthy volunteers. Drug Alcohol Depend. 2002 Sep 01; 68(1):23-33. View in: PubMed

  224. Wachtel SR, ElSohly MA, Ross SA, Ambre J, de Wit H. Comparison of the subjective effects of Delta(9)-tetrahydrocannabinol and marijuana in humans. Psychopharmacology (Berl). 2002 Jun; 161(4):331-9. View in: PubMed

  225. King AC, Houle T, de Wit H, Holdstock L, Schuster A. Biphasic alcohol response differs in heavy versus light drinkers. Alcohol Clin Exp Res. 2002 Jun; 26(6):827-35. View in: PubMed

  226. Söderpalm AH, de Wit H. Effects of stress and alcohol on subjective state in humans. Alcohol Clin Exp Res. 2002 Jun; 26(6):818-26. View in: PubMed

  227. Cousins MS, Roberts DC, de Wit H. GABA(B) receptor agonists for the treatment of drug addiction: a review of recent findings. Drug Alcohol Depend. 2002 Feb 01; 65(3):209-20. View in: PubMed

  228. Schleifer LA, Justice AJ, de Wit H. Lack of effects of acute estradiol on mood in postmenopausal women. Pharmacol Biochem Behav. 2002 Jan-Feb; 71(1-2):71-7. View in: PubMed

  229. Uftring SJ, Wachtel SR, Chu D, McCandless C, Levin DN, de Wit H. An fMRI study of the effect of amphetamine on brain activity. Neuropsychopharmacology. 2001 Dec; 25(6):925-35. View in: PubMed

  230. Wachtel SR, de Wit H. Lack of effect of intravenous hydrocortisone on mood in humans: a preliminary study. Behav Pharmacol. 2001 Sep; 12(5):373-6. View in: PubMed

  231. Enggasser JL, de Wit H. Haloperidol reduces stimulant and reinforcing effects of ethanol in social drinkers. Alcohol Clin Exp Res. 2001 Oct; 25(10):1448-56. View in: PubMed

  232. Cousins MS, Stamat HM, de Wit H. Acute doses of d-amphetamine and bupropion increase cigarette smoking. Psychopharmacology (Berl). 2001 Sep; 157(3):243-53. View in: PubMed

  233. Söderpalm AH, Schuster A, de Wit H. Antiemetic efficacy of smoked marijuana: subjective and behavioral effects on nausea induced by syrup of ipecac. Pharmacol Biochem Behav. 2001 Jul-Aug; 69(3-4):343-50. View in: PubMed

  234. de Wit H, Schmitt L, Purdy R, Hauger R. Effects of acute progesterone administration in healthy postmenopausal women and normally-cycling women. Psychoneuroendocrinology. 2001 Oct; 26(7):697-710. View in: PubMed

  235. Cousins MS, Stamat HM, de Wit H. Effects of a single dose of baclofen on self-reported subjective effects and tobacco smoking. Nicotine Tob Res. 2001 May; 3(2):123-9. View in: PubMed

  236. Holdstock L, de Wit H. Individual differences in responses to ethanol and d-amphetamine: a within-subject study. Alcohol Clin Exp Res. 2001 Apr; 25(4):540-8. View in: PubMed

  237. Wachtel SR, Charnot A, de Wit H. Acute hydrocortisone administration does not affect subjective responses to d-amphetamine in humans. Psychopharmacology (Berl). 2001 Jan; 153(3):380-8. View in: PubMed

  238. Doty P, de Wit H. Effects of naltrexone pretreatment on the subjective and performance effects of ethanol in social drinkers. Behav Pharmacol. 1995 Jun; 6(4):386-394. View in: PubMed

  239. Mitchell SH, de Wit H, Zacny JP. Effects of varying ethanol dose on cigarette consumption in healthy normal volunteers. Behav Pharmacol. 1995 Jun; 6(4):359-365. View in: PubMed

  240. Doty P, Zacny JP, de Wit H. Effects of ondansetron pretreatment on acute responses to ethanol in social drinkers. Behav Pharmacol. 1994 Aug; 5(4 And 5):461-469. View in: PubMed

  241. Mitchell SH, de Wit H, Zacny JP. Effects of varying the "openness" of an economy on responding for cigarettes. Behav Pharmacol. 1994 Apr; 5(2):159-166. View in: PubMed

  242. Brauer LH, Buican B, de Wit H. Effects of caffeine deprivation on taste and mood. Behav Pharmacol. 1994 Apr; 5(2):111-118. View in: PubMed

  243. Dohrn CS, Lichtor JL, Finn RS, Uitvlugt A, Coalson DW, Rupani G, de Wit H, Zacny JP. Subjective and psychomotor effects of nitrous oxide in healthy volunteers. Behav Pharmacol. 1992 Feb; 3(1):19-30. View in: PubMed

  244. Zacny JP, de Wit H. Effects of food deprivation on responses to marijuana in humans. Behav Pharmacol. 1989; 1(2):177-185. View in: PubMed

  245. de Wit H. Laboratory-based assessment of alcohol craving in social drinkers. Addiction. 2000 Aug; 95 Suppl 2:S165-9. View in: PubMed

  246. Feola TW, de Wit H, Richards JB. Effects of d-amphetamine and alcohol on a measure of behavioral inhibition in rats. Behav Neurosci. 2000 Aug; 114(4):838-848. View in: PubMed

  247. de Wit H, Crean J, Richards JB. Effects of d-amphetamine and ethanol on a measure of behavioral inhibition in humans. Behav Neurosci. 2000 Aug; 114(4):830-7. View in: PubMed

  248. Holdstock L, de Wit H. Effects of ethanol at four phases of the menstrual cycle. Psychopharmacology (Berl). 2000 Jul; 150(4):374-82. View in: PubMed

  249. Justice AJ, De Wit H. Acute effects of d-amphetamine during the early and late follicular phases of the menstrual cycle in women. Pharmacol Biochem Behav. 2000 Jul; 66(3):509-15. View in: PubMed

  250. Holdstock L, King AC, de Wit H. Subjective and objective responses to ethanol in moderate/heavy and light social drinkers. Alcohol Clin Exp Res. 2000 Jun; 24(6):789-94. View in: PubMed

  251. Crean JP, de Wit H, Richards JB. Reward discounting as a measure of impulsive behavior in a psychiatric outpatient population. Exp Clin Psychopharmacol. 2000 May; 8(2):155-62. View in: PubMed

  252. Wachtel SR, de Wit H. Naltrexone does not block the subjective effects of oral Delta(9)-tetrahydrocannabinol in humans. Drug Alcohol Depend. 2000 Jun 01; 59(3):251-60. View in: PubMed

  253. Holdstock L, de Wit H. Individual differences in subjective responses to ethanol and triazolam. Behav Pharmacol. 1999 May; 10(3):283-95. View in: PubMed

  254. Wachtel SR, de Wit H. Subjective and behavioral effects of repeated d-amphetamine in humans. Behav Pharmacol. 1999 May; 10(3):271-81. View in: PubMed

  255. Justice AJ, de Wit H. Acute effects of estradiol pretreatment on the response to d-amphetamine in women. Neuroendocrinology. 2000 Jan; 71(1):51-9. View in: PubMed

  256. Kirk JM, de Wit H. Individual differences in the priming effect of ethanol in social drinkers. J Stud Alcohol. 2000 Jan; 61(1):64-71. View in: PubMed

  257. Rukstalis M, de Wit H. Effects of triazolam at three phases of the menstrual cycle. J Clin Psychopharmacol. 1999 Oct; 19(5):450-8. View in: PubMed

  258. de Wit H, Svenson J, York A. Non-specific effect of naltrexone on ethanol consumption in social drinkers. Psychopharmacology (Berl). 1999 Sep 01; 146(1):33-41. View in: PubMed

  259. Justice AJ, de Wit H. Acute effects of d-amphetamine during the follicular and luteal phases of the menstrual cycle in women. Psychopharmacology (Berl). 1999 Jul; 145(1):67-75. View in: PubMed

  260. Kirk JM, de Wit H. Responses to oral delta9-tetrahydrocannabinol in frequent and infrequent marijuana users. Pharmacol Biochem Behav. 1999 May; 63(1):137-42. View in: PubMed

  261. Holdstock L, de Wit H. Ethanol impairs saccadic and smooth pursuit eye movements without producing self-reports of sedation. Alcohol Clin Exp Res. 1999 Apr; 23(4):664-72. View in: PubMed

  262. Richards JB, Zhang L, Mitchell SH, de Wit H. Delay or probability discounting in a model of impulsive behavior: effect of alcohol. J Exp Anal Behav. 1999 Mar; 71(2):121-43. View in: PubMed

  263. Holdstock L, de Wit H. Individual differences in the biphasic effects of ethanol. Alcohol Clin Exp Res. 1998 Dec; 22(9):1903-11. View in: PubMed

  264. Zacny JP, Mitchell SH, Cramblett MJ, de Wit H. The effects of ethanol on the relative preference for cigarettes. Behav Pharmacol. 1997 Feb; 8(1):75-81. View in: PubMed

  265. de Wit H. Individual differences in acute effects of drugs in humans: their relevance to risk for abuse. NIDA Res Monogr. 1998 Mar; 169:176-87. View in: PubMed

  266. Cooper M, Metz J, de Wit H, Cook E, Lorenz J, Brown T. Interclass drug effects and changes in regional brain glucose metabolism. Psychopharmacol Bull. 1998; 34(2):229-32. View in: PubMed

  267. Kirk JM, Doty P, De Wit H. Effects of expectancies on subjective responses to oral delta9-tetrahydrocannabinol. Pharmacol Biochem Behav. 1998 Feb; 59(2):287-93. View in: PubMed

  268. Doty P, Kirk JM, Cramblett MJ, de Wit H. Behavioral responses to ethanol in light and moderate social drinkers following naltrexone pretreatment. Drug Alcohol Depend. 1997 Aug 25; 47(2):109-16. View in: PubMed

  269. de Wit H, Clark M, Brauer LH. Effects of d-amphetamine in grouped versus isolated humans. Pharmacol Biochem Behav. 1997 May-Jun; 57(1-2):333-40. View in: PubMed

  270. Richards JB, Mitchell SH, de Wit H, Seiden LS. Determination of discount functions in rats with an adjusting-amount procedure. J Exp Anal Behav. 1997 May; 67(3):353-66. View in: PubMed

  271. de Wit H, Rukstalis M. Acute effects of triazolam in women: relationships with progesterone, estradiol and allopregnanolone. Psychopharmacology (Berl). 1997 Mar; 130(1):69-78. View in: PubMed

  272. Brauer LH, Johanson CE, Schuster CR, Rothman RB, de Wit H. Evaluation of phentermine and fenfluramine, alone and in combination, in normal, healthy volunteers. Neuropsychopharmacology. 1996 Apr; 14(4):233-41. View in: PubMed

  273. Brauer LH, Ambre J, De Wit H. Acute tolerance to subjective but not cardiovascular effects of d-amphetamine in normal, healthy men. J Clin Psychopharmacol. 1996 Feb; 16(1):72-6. View in: PubMed

  274. Mitchell SH, Laurent CL, de Wit H. Interaction of expectancy and the pharmacological effects of d-amphetamine: subjective effects and self-administration. Psychopharmacology (Berl). 1996 Jun; 125(4):371-8. View in: PubMed

  275. Brauer LH, de Wit H. Subjective responses to d-amphetamine alone and after pimozide pretreatment in normal, healthy volunteers. Biol Psychiatry. 1996 Jan 01; 39(1):26-32. View in: PubMed

  276. Brauer LH, Rukstalis MR, de Wit H. Acute subjective responses to paroxetine in normal volunteers. Drug Alcohol Depend. 1995 Oct; 39(3):223-30. View in: PubMed

  277. Dohrn CS, Lichtor JL, Coalson DW, Uitvlugt A, de Wit H, Zacny JP. Reinforcing effects of extended inhalation of nitrous oxide in humans. Drug Alcohol Depend. 1993 Feb; 31(3):265-80. View in: PubMed

  278. Chutuape MA, de Wit H. Relationship between subjective effects and drug preferences: ethanol and diazepam. Drug Alcohol Depend. 1994 Feb; 34(3):243-51. View in: PubMed

  279. de Wit H, Doty P. Preference for ethanol and diazepam in light and moderate social drinkers: a within-subjects study. Psychopharmacology (Berl). 1994 Aug; 115(4):529-38. View in: PubMed

  280. de Wit H, Dudish S, Ambre J. Subjective and behavioral effects of diazepam depend on its rate of onset. Psychopharmacology (Berl). 1993; 112(2-3):324-30. View in: PubMed

  281. de Wit H, Bodker B. Personality and drug preferences in normal volunteers. Int J Addict. 1994 Oct; 29(12):1617-30. View in: PubMed

  282. Mitchell SH, de Wit H, Zacny JP. Caffeine withdrawal symptoms and self-administration following caffeine deprivation. Pharmacol Biochem Behav. 1995 Aug; 51(4):941-5. View in: PubMed

  283. Doty P, de Wit H. Effect of setting on the reinforcing and subjective effects of ethanol in social drinkers. Psychopharmacology (Berl). 1995 Mar; 118(1):19-27. View in: PubMed

  284. de Wit H, McCracken SM, Uhlenhuth EH, Johanson CE. Diazepam preference in subjects seeking treatment for anxiety. NIDA Res Monogr. 1987; 76:248-54. View in: PubMed

  285. de Wit H, Metz J, Cooper M. The effects of 0.8 g.kg ethanol on cerebral metabolism and mood in normal volunteers. NIDA Res Monogr. 1989; 95:450. View in: PubMed

  286. Zacny JP, de Wit H. Effects of food deprivation on subjective responses to d-amphetamine in humans. Pharmacol Biochem Behav. 1989 Dec; 34(4):791-5. View in: PubMed

  287. de Wit H, Pierri J, Johanson CE. Assessing pentobarbital preference in normal volunteers using a cumulative dosing procedure. Psychopharmacology (Berl). 1989; 99(3):416-21. View in: PubMed

  288. Zacny JP, de Wit H. Effects of a 24-hour fast on cigarette smoking in humans. Br J Addict. 1990 Apr; 85(4):555-60. View in: PubMed

  289. de Wit H, Metz J, Wagner N, Cooper M. Behavioral and subjective effects of ethanol: relationship to cerebral metabolism using PET. Alcohol Clin Exp Res. 1990 Jun; 14(3):482-9. View in: PubMed

  290. McCracken SG, de Wit H, Uhlenhuth EH, Johanson CE. Preference for diazepam in anxious adults. J Clin Psychopharmacol. 1990 Jun; 10(3):190-6. View in: PubMed

  291. de Wit H, McCracken SG. Ethanol self-administration in males with and without an alcoholic first-degree relative. Alcohol Clin Exp Res. 1990 Feb; 14(1):63-70. View in: PubMed

  292. de Wit H, Metz J, Wagner N, Cooper M. Effects of diazepam on cerebral metabolism and mood in normal volunteers. Neuropsychopharmacology. 1991 Aug; 5(1):33-41. View in: PubMed

  293. de Wit H. Diazepam preference in males with and without an alcoholic first-degree relative. Alcohol Clin Exp Res. 1991 Aug; 15(4):593-600. View in: PubMed

  294. Zacny JP, de Wit H. Effects of food deprivation on subjective effects and self-administration of marijuana in humans. Psychol Rep. 1991 Jun; 68(3 Pt 2):1263-74. View in: PubMed

  295. de Wit H, Metz J, Cooper M. Effects of ethanol, diazepam and amphetamines on cerebral metabolic rate: PET studies using FDG. NIDA Res Monogr. 1990; 105:61-7. View in: PubMed

  296. De Wit H. Preference procedures for testing the abuse liability of drugs in humans. Br J Addict. 1991 Dec; 86(12):1579-86. View in: PubMed

  297. de Wit H, Griffiths RR. Testing the abuse liability of anxiolytic and hypnotic drugs in humans. Drug Alcohol Depend. 1991 Jun; 28(1):83-111. View in: PubMed

  298. Zacny JP, Lichtor JL, Zaragoza JG, de Wit H. Subjective and behavioral responses to intravenous fentanyl in healthy volunteers. Psychopharmacology (Berl). 1992; 107(2-3):319-26. View in: PubMed

  299. Zacny JP, Bodker BK, de Wit H. Effects of setting on the subjective and behavioral effects of d-amphetamine in humans. Addict Behav. 1992; 17(1):27-33. View in: PubMed

  300. Zacny JP, de Wit H. The effects of a restricted feeding regimen on cigarette smoking in humans. Addict Behav. 1992; 17(2):149-57. View in: PubMed

  301. Zacny JP, Lichtor JL, Zaragoza JG, de Wit H. Effects of fasting on responses to intravenous fentanyl in healthy volunteers. J Subst Abuse. 1992; 4(2):197-207. View in: PubMed

  302. de Wit H, Metz J, Cooper M. Studying psychoactive drugs with positron emission tomography: relationships between mood and metabolic rate. NIDA Res Monogr. 1992; 124:117-34. View in: PubMed

  303. Cole-Harding S, de Wit H. Self-administration of pentobarbital in light and moderate alcohol drinkers. Pharmacol Biochem Behav. 1992 Oct; 43(2):563-9. View in: PubMed

  304. Zacny JP, Lichtor JL, de Wit H. Subjective, behavioral, and physiologic responses to intravenous dezocine in healthy volunteers. Anesth Analg. 1992 Apr; 74(4):523-30. View in: PubMed