Ming Xu

Research Summary
My long-term research interest is to understand mechanisms underlying drug addiction and to find possible treatment. We use behavioral, genetic, anatomical and molecular biological methods. One major research project is to identify mechanisms and neuronal circuits associated with reconsolidation and extinction of cocaine-induced reward memory. Another project is to develop a novel method of using skin stem cells to deliver therapeutic genes to combat the abuse of cocaine, ethanol, nicotine and their co-abuse.
drug abuse, mechanisms, treatment
  • Peking University, Beijing, P.R. China, BS Chemistry 01/1982
  • University of Texas Southwestern Medical Center, Dallas, TX, Ph.D. Molecular Biology 03/1989
  • Massachusetts Institute of Technology, Boston, MA, postdoc Neurobiology 12/1995
Biosciences Graduate Program Association
  1. Wang CZ, Wan JY, Wan J, Wang S, Luo Y, Zeng J, Yao H, Zhang CF, Zhang QH, Sawadogo WR, Xu M, Du W, Qi LW, Li P, Yuan CS. Human intestinal microbiota derived metabolism signature from a North American native botanical Oplopanax horridus with UPLC/Q-TOF-MS analysis. Biomed Chromatogr. 2020 Oct; 34(10):e4911. View in: PubMed

  2. Li Y, Kong Q, Yue J, Gou X, Xu M, Wu X. Genome-edited skin epidermal stem cells protect mice from cocaine-seeking behaviour and cocaine overdose. Nat Biomed Eng. 2019 Feb; 3(2):105-113. View in: PubMed

  3. Wang CZ, Zhang CF, Zhang QH, Hesse-Fong J, Lager M, Du W, Xu M, Yuan CS. Fecal metabolomic dataset of American ginseng-treated DSS mice: Correlation between ginseng enteric inflammation inhibition and its biological signatures. Data Brief. 2018 Dec; 21:1403-1408. View in: PubMed

  4. Wang CZ, Yao H, Zhang CF, Chen L, Wan JY, Huang WH, Zeng J, Zhang QH, Liu Z, Yuan J, Bi Y, Sava-Segal C, Du W, Xu M, Yuan CS. American ginseng microbial metabolites attenuate DSS-induced colitis and abdominal pain. Int Immunopharmacol. 2018 Nov; 64:246-251. View in: PubMed

  5. Kesarwani M, Kincaid Z, Gomaa A, Huber E, Rohrabaugh S, Siddiqui Z, Bouso MF, Latif T, Xu M, Komurov K, Mulloy JC, Cancelas JA, Grimes HL, Azam M. Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia. Nat Med. 2017 Apr; 23(4):472-482. View in: PubMed

  6. Solís O, Garcia-Montes JR, González-Granillo A, Xu M, Moratalla R. Dopamine D3 Receptor Modulates l-DOPA-Induced Dyskinesia by Targeting D1 Receptor-Mediated Striatal Signaling. Cereb Cortex. 2017 01 01; 27(1):435-446. View in: PubMed

  7. Soto PL, Hiranita T, Xu M, Hursh SR, Grandy DK, Katz JL. Dopamine D2-Like Receptors and Behavioral Economics of Food Reinforcement. Neuropsychopharmacology. 2016 Mar; 41(4):971-8. View in: PubMed

  8. Yan Y, Newman AH, Xu M. Dopamine D1 and D3 receptors mediate reconsolidation of cocaine memories in mouse models of drug self-administration. Neuroscience. 2014 Oct 10; 278:154-64. View in: PubMed

  9. Laronda MM, Duncan FE, Hornick JE, Xu M, Pahnke JE, Whelan KA, Shea LD, Woodruff TK. Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue. J Assist Reprod Genet. 2014 Aug; 31(8):1013-28. View in: PubMed

  10. Zhang A, Xu M, Mo YY. Role of the lncRNA-p53 regulatory network in cancer. J Mol Cell Biol. 2014 Jun; 6(3):181-91. View in: PubMed

  11. Zhang X, Zhang W, Ma SF, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Nourai M, Wade MS, Prchal JT, Garcia JGN, Machado RF, Gordeuk VR. Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing. Blood Cells Mol Dis. 2014 Jan; 52(1):35-45. View in: PubMed

  12. Yan Y, Kong H, Wu EJ, Newman AH, Xu M. Dopamine D3 receptors regulate reconsolidation of cocaine memory. Neuroscience. 2013 Jun 25; 241:32-40. View in: PubMed

  13. Shao W, Zhang SZ, Tang M, Zhang XH, Zhou Z, Yin YQ, Zhou QB, Huang YY, Liu YJ, Wawrousek E, Chen T, Li SB, Xu M, Zhou JN, Hu G, Zhou JW. Suppression of neuroinflammation by astrocytic dopamine D2 receptors via aB-crystallin. Nature. 2013 Feb 07; 494(7435):90-4. View in: PubMed

  14. Cao G, Zhu J, Zhong Q, Shi C, Dang Y, Han W, Liu X, Xu M, Chen T. Distinct roles of methamphetamine in modulating spatial memory consolidation, retrieval, reconsolidation and the accompanying changes of ERK and CREB activation in hippocampus and prefrontal cortex. Neuropharmacology. 2013 Apr; 67:144-54. View in: PubMed

  15. Jiao ZX, Xu M, Woodruff TK. Age-associated alteration of oocyte-specific gene expression in polar bodies: potential markers of oocyte competence. Fertil Steril. 2012 Aug; 98(2):480-6. View in: PubMed

  16. Xu M, Pavone ME, Woodruff T. Fruitful progress to fertility: preserving oocytes from chemodestruction. Nat Med. 2011 Dec 06; 17(12):1562-3. View in: PubMed

  17. Kong H, Xu M. Exploring mechanisms underlying extinction of cue-elicited cocaine seeking. Curr Neuropharmacol. 2011 Mar; 9(1):8-11. View in: PubMed

  18. Shikanov A, Zhang Z, Xu M, Smith RM, Rajan A, Woodruff TK, Shea LD. Fibrin encapsulation and vascular endothelial growth factor delivery promotes ovarian graft survival in mice. Tissue Eng Part A. 2011 Dec; 17(23-24):3095-104. View in: PubMed

  19. Antenos M, Lei L, Xu M, Malipatil A, Kiesewetter S, Woodruff TK. Role of PCSK5 expression in mouse ovarian follicle development: identification of the inhibin a- and ß-subunits as candidate substrates. PLoS One. 2011 Mar 08; 6(3):e17348. View in: PubMed

  20. Kong H, Kuang W, Li S, Xu M. Activation of dopamine D3 receptors inhibits reward-related learning induced by cocaine. Neuroscience. 2011 Mar 10; 176:152-61. View in: PubMed

  21. Xu M, Fazleabas AT, Shikanov A, Jackson E, Barrett SL, Hirshfeld-Cytron J, Kiesewetter SE, Shea LD, Woodruff TK. In vitro oocyte maturation and preantral follicle culture from the luteal-phase baboon ovary produce mature oocytes. Biol Reprod. 2011 Apr; 84(4):689-97. View in: PubMed

  22. Chen L, Xu M. Dopamine D1 and D3 receptors are differentially involved in cue-elicited cocaine seeking. J Neurochem. 2010 Jul; 114(2):530-41. View in: PubMed

  23. Ren Z, Sun WL, Jiao H, Zhang D, Kong H, Wang X, Xu M. Dopamine D1 and N-methyl-D-aspartate receptors and extracellular signal-regulated kinase mediate neuronal morphological changes induced by repeated cocaine administration. Neuroscience. 2010 Jun 16; 168(1):48-60. View in: PubMed

  24. Fan X, Xu M, Hess EJ. D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD. Neurobiol Dis. 2010 Jan; 37(1):228-36. View in: PubMed

  25. Zhou FW, Jin Y, Matta SG, Xu M, Zhou FM. An ultra-short dopamine pathway regulates basal ganglia output. J Neurosci. 2009 Aug 19; 29(33):10424-35. View in: PubMed

  26. Shikanov A, Xu M, Woodruff TK, Shea LD. Interpenetrating fibrin-alginate matrices for in vitro ovarian follicle development. Biomaterials. 2009 Oct; 30(29):5476-85. View in: PubMed

  27. Xu M, Barrett SL, West-Farrell E, Kondapalli LA, Kiesewetter SE, Shea LD, Woodruff TK. In vitro grown human ovarian follicles from cancer patients support oocyte growth. Hum Reprod. 2009 Oct; 24(10):2531-40. View in: PubMed

  28. Xu M, West-Farrell ER, Stouffer RL, Shea LD, Woodruff TK, Zelinski MB. Encapsulated three-dimensional culture supports development of nonhuman primate secondary follicles. Biol Reprod. 2009 Sep; 81(3):587-94. View in: PubMed

  29. Campioni MR, Xu M, McGehee DS. Stress-induced changes in nucleus accumbens glutamate synaptic plasticity. J Neurophysiol. 2009 Jun; 101(6):3192-8. View in: PubMed

  30. Liu XY, Mao LM, Zhang GC, Papasian CJ, Fibuch EE, Lan HX, Zhou HF, Xu M, Wang JQ. Activity-dependent modulation of limbic dopamine D3 receptors by CaMKII. Neuron. 2009 Feb 12; 61(3):425-38. View in: PubMed

  31. Xu M, Banc A, Woodruff TK, Shea LD. Secondary follicle growth and oocyte maturation by culture in alginate hydrogel following cryopreservation of the ovary or individual follicles. Biotechnol Bioeng. 2009 Jun 01; 103(2):378-86. View in: PubMed

  32. Hu XT, Nasif FJ, Zhang J, Xu M. Fos regulates neuronal activity in the nucleus accumbens. Neurosci Lett. 2008 Dec 19; 448(1):157-60. View in: PubMed

  33. Caine SB, Thomsen M, Gabriel KI, Berkowitz JS, Gold LH, Koob GF, Tonegawa S, Zhang J, Xu M. Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice. J Neurosci. 2007 Nov 28; 27(48):13140-50. View in: PubMed

  34. Jiao H, Zhang L, Gao F, Lou D, Zhang J, Xu M. Dopamine D(1) and D(3) receptors oppositely regulate NMDA- and cocaine-induced MAPK signaling via NMDA receptor phosphorylation. J Neurochem. 2007 Oct; 103(2):840-8. View in: PubMed

  35. Shi J, Zhao Y, Ishii T, Hu W, Sozer S, Zhang W, Bruno E, Lindgren V, Xu M, Hoffman R. Effects of chromatin-modifying agents on CD34+ cells from patients with idiopathic myelofibrosis. Cancer Res. 2007 Jul 01; 67(13):6417-24. View in: PubMed

  36. Ciurea SO, Merchant D, Mahmud N, Ishii T, Zhao Y, Hu W, Bruno E, Barosi G, Xu M, Hoffman R. Pivotal contributions of megakaryocytes to the biology of idiopathic myelofibrosis. Blood. 2007 Aug 01; 110(3):986-93. View in: PubMed

  37. Zhang J, Zhang L, Jiao H, Zhang Q, Zhang D, Lou D, Katz JL, Xu M. c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. J Neurosci. 2006 Dec 20; 26(51):13287-96. View in: PubMed

  38. Cui C, Xu M, Atzori M. Voltage-dependent block of N-methyl-D-aspartate receptors by dopamine D1 receptor ligands. Mol Pharmacol. 2006 Nov; 70(5):1761-70. View in: PubMed

  39. Ishii T, Bruno E, Hoffman R, Xu M. Involvement of various hematopoietic-cell lineages by the JAK2V617F mutation in polycythemia vera. Blood. 2006 Nov 01; 108(9):3128-34. View in: PubMed

  40. Araki H, Mahmud N, Milhem M, Nunez R, Xu M, Beam CA, Hoffman R. Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents. Exp Hematol. 2006 Feb; 34(2):140-9. View in: PubMed

  41. Zhang D, Zhang L, Tang Y, Zhang Q, Lou D, Sharp FR, Zhang J, Xu M. Repeated cocaine administration induces gene expression changes through the dopamine D1 receptors. Neuropsychopharmacology. 2005 Aug; 30(8):1443-54. View in: PubMed

  42. Xu M, Bruno E, Chao J, Huang S, Finazzi G, Fruchtman SM, Popat U, Prchal JT, Barosi G, Hoffman R. Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases. Blood. 2005 Jun 01; 105(11):4508-15. View in: PubMed

  43. Xu M, Bruno E, Chao J, Ni H, Lindgren V, Nunez R, Mahmud N, Finazzi G, Fruchtman SM, Popat U, Liu E, Prchal JT, Rondelli D, Barosi G, Hoffman R. The constitutive mobilization of bone marrow-repopulating cells into the peripheral blood in idiopathic myelofibrosis. Blood. 2005 Feb 15; 105(4):1699-705. View in: PubMed

  44. Zhang L, Lou D, Jiao H, Zhang D, Wang X, Xia Y, Zhang J, Xu M. Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. J Neurosci. 2004 Mar 31; 24(13):3344-54. View in: PubMed

  45. Zhang J, Dong M, Li L, Fan Y, Pathre P, Dong J, Lou D, Wells JM, Olivares-Villagómez D, Van Kaer L, Wang X, Xu M. Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15782-7. View in: PubMed

  46. Zheng W, Xie W, Zhang J, Strong JA, Wang L, Yu L, Xu M, Lu L. Function of gamma-aminobutyric acid receptor/channel rho 1 subunits in spinal cord. J Biol Chem. 2003 Nov 28; 278(48):48321-9. View in: PubMed

  47. Zhang D, Zhang L, Lou DW, Nakabeppu Y, Zhang J, Xu M. The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression. J Neurochem. 2002 Sep; 82(6):1453-64. View in: PubMed

  48. Zhang J, McQuade JM, Vorhees CV, Xu M. Hippocampal expression of c-fos is not essential for spatial learning. Synapse. 2002 Nov; 46(2):91-9. View in: PubMed

  49. Zhang J, Zhang D, McQuade JS, Behbehani M, Tsien JZ, Xu M. c-fos regulates neuronal excitability and survival. Nat Genet. 2002 Apr; 30(4):416-20. View in: PubMed

  50. Zhang J, Xu M. Apoptotic DNA fragmentation and tissue homeostasis. Trends Cell Biol. 2002 Feb; 12(2):84-9. View in: PubMed

  51. Boulares AH, Zoltoski AJ, Yakovlev A, Xu M, Smulson ME. Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis. J Biol Chem. 2001 Oct 12; 276(41):38185-92. View in: PubMed

  52. Xu M, Guo Y, Vorhees CV, Zhang J. Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor. Brain Res. 2000 Jan 03; 852(1):198-207. View in: PubMed

  53. Lan Z, Wu H, Li W, Wu S, Lu L, Xu M, Dai W. Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway. Blood. 2000 Jan 15; 95(2):633-8. View in: PubMed

  54. Zhang J, Wang X, Bove KE, Xu M. DNA fragmentation factor 45-deficient cells are more resistant to apoptosis and exhibit different dying morphology than wild-type control cells. J Biol Chem. 1999 Dec 24; 274(52):37450-4. View in: PubMed

  55. Dracheva S, Xu M, Kelley KA, Haroutunian V, Holstein GR, Haun S, Silverstein JH, Sealfon SC. Paradoxical locomotor behavior of dopamine D1 receptor transgenic mice. Exp Neurol. 1999 May; 157(1):169-79. View in: PubMed

  56. Zhang J, Liu X, Scherer DC, van Kaer L, Wang X, Xu M. Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12480-5. View in: PubMed

  57. Koeltzow TE, Xu M, Cooper DC, Hu XT, Tonegawa S, Wolf ME, White FJ. Alterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant mice. J Neurosci. 1998 Mar 15; 18(6):2231-8. View in: PubMed

  58. Xu M, Koeltzow TE, Santiago GT, Moratalla R, Cooper DC, Hu XT, White NM, Graybiel AM, White FJ, Tonegawa S. Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors. Neuron. 1997 Oct; 19(4):837-48. View in: PubMed

  59. Moratalla R, Xu M, Tonegawa S, Graybiel AM. Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14928-33. View in: PubMed

  60. Xu M, Hu XT, Cooper DC, Moratalla R, Graybiel AM, White FJ, Tonegawa S. Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice. Cell. 1994 Dec 16; 79(6):945-55. View in: PubMed

  61. Xu M, Moratalla R, Gold LH, Hiroi N, Koob GF, Graybiel AM, Tonegawa S. Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell. 1994 Nov 18; 79(4):729-42. View in: PubMed

  62. Xu M, Barnard MB, Rose SM, Cockerill PN, Huang SY, Garrard WT. Transcription termination and chromatin structure of the active immunoglobulin kappa gene locus. J Biol Chem. 1986 Mar 15; 261(8):3838-45. View in: PubMed

  63. Huang SY, Barnard MB, Xu M, Matsui S, Rose SM, Garrard WT. The active immunoglobulin kappa chain gene is packaged by non-ubiquitin-conjugated nucleosomes. Proc Natl Acad Sci U S A. 1986 Jun; 83(11):3738-42. View in: PubMed

  64. Xu M, Hammer RE, Blasquez VC, Jones SL, Garrard WT. Immunoglobulin kappa gene expression after stable integration. II. Role of the intronic MAR and enhancer in transgenic mice. J Biol Chem. 1989 Dec 15; 264(35):21190-5. View in: PubMed

  65. Blasquez VC, Xu M, Moses SC, Garrard WT. Immunoglobulin kappa gene expression after stable integration. I. Role of the intronic MAR and enhancer in plasmacytoma cells. J Biol Chem. 1989 Dec 15; 264(35):21183-9. View in: PubMed

  66. Yuanyuan Li, Qingyao Kong, Jiping Yue, Xuewen Gou, Ming Xu* and Xiaoyang Wu*. Genome-edited skin epidermal stem cells
    protect mice from cocaine-seeking behaviour
    and cocaine overdose. Nature Biomedical Engineering. 2018.::::