Nanduri R. Prabhakar, DSC PhD

Nanduri R. Prabhakar, Ph.D., D.Sc.

Harold Hines Jr. Professor of Medicine

Director, Center for Systems Biology

Director, Oxygen Sensing Department of Medicine



The revolutionary advances in cell and molecular biology as well as in genetic engineering in the past half-a-century have provided spectacular insights into our understanding of structure and function of biological systems at the molecular, cellular and sub-cellular levels. Shifting the research emphasis from organ (or from the whole body levels) to cellular and molecular physiology has resulted in a rapid decline in research on physiology at the systems level. While the reductionist approaches are powerful, they have brought into focus a major gap that has developed between our understanding of the molecular/cellular alterations and their impact at the organ and/or whole animal level. Integrative physiology, on the other hand, embraces the concepts of cell/molecular physiology, biochemistry and applies these concepts and experimental approaches to understand the function at the level of whole animal or organ. Realizing its importance, the University of Chicago established the Institute for Integrative Physiology (IIP) at the Biological Sciences Division as of October 2010. The main missions of IIP are to provide intellectual home for faculty members interested in various areas of Physiology to foster interactive research programs and oversee physiology education to medical, graduate and undergraduate students. These missions are supported by exceptional faculty in the IIP. We believe that IIP reaches far beyond the BSD to enhance the national and international visibility of Physiological research at the University of Chicago and provide training to the next generation of leaders in Physiology.

Ruhr University
Bochum, Federal Republic of Germany
D.Sc. - Biology
1982

M.S. University
Baroda, India
Ph.D. - Physiology
1979

P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia.
P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia. Am J Respir Cell Mol Biol. 2024 Feb; 70(2):110-118.
PMID: 37874694

Correction: Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.
Correction: Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells. PLoS One. 2024; 19(1):e0297301.
PMID: 38206933

P300/CBP Regulates HIF-1 Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia.
P300/CBP Regulates HIF-1 Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia. Am J Respir Cell Mol Biol. 2023 Oct 24.
PMID: 37874694

Editorial: Vascular pathophysiology in hypoxia.
Editorial: Vascular pathophysiology in hypoxia. Front Physiol. 2023; 14:1235383.
PMID: 37485063

Hypoxia sensing requires H2S-dependent persulfidation of olfactory receptor 78.
Hypoxia sensing requires H2S-dependent persulfidation of olfactory receptor 78. Sci Adv. 2023 07 07; 9(27):eadf3026.
PMID: 37406126

Carotid body hypersensitivity in intermittent hypoxia and obtructive sleep apnoea.
Carotid body hypersensitivity in intermittent hypoxia and obtructive sleep apnoea. J Physiol. 2023 Dec; 601(24):5481-5494.
PMID: 37029496

Gasotransmitter modulation of hypoglossal motoneuron activity.
Gasotransmitter modulation of hypoglossal motoneuron activity. Elife. 2023 01 19; 12.
PMID: 36656752

A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans.
A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans. Sci Adv. 2022 Nov 25; 8(47):eade1942.
PMID: 36417539

Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells.
Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells. Sci Rep. 2022 10 13; 12(1):17167.
PMID: 36229484

Carotid body responses to O2 and CO2 in hypoxia-tolerant naked mole rats.
Carotid body responses to O2 and CO2 in hypoxia-tolerant naked mole rats. Acta Physiol (Oxf). 2022 10; 236(2):e13851.
PMID: 35757963

View All Publications

Elected Fellow of the American Physiological Society
2017

AAIMS Silver Jubilee Oration Award
2017

Michael de Burgh Daly Award, Physiological Society, U.K.
2016

Inaugural Lahiri-Cherniack Lecture, American Physiological Society
2016

Plenary Lecture, Oxford Meeting, Sydney, Australia
2015

Elected Foreign Member of National Academy of Sciences India
2015

Inaugural C. von Euler Lecture, Karolinska Nobel Institutet, Stockholm, Sweden
2014

Plenary Lecture, PanAm Physiological Congress, Brazil
2014

Prof. Mahabalinos Award, Physiological Society of India
2014

Mario Toppo Distinguished Scientist Award, ASIOA
2013

Julius H.Comroe Distinguished Lecture Award American Physiological Society
2012

Plenary Lecture. British Physiological Soc. Birmingham, U.K.
2010

Neil S. Cherniack Lecture, Case Western Reserve University, Cleveland
2008

A.S. Paintal Award, University of Delhi
2008

Dr. P.C.Roy Oration Award. Indian Physiological Society
2007

Plenary Lecture, Brazilian Physiological Society
2005

Plenary Lecture, O2 Homeostasis, University of Cardiff, U.K.
2005

Nobel Forum: Invited Speaker, Nobel Symposium on Oxygen Biology, Stockholm Sweden
2004