Narayanan Kasthuri

Assistant Professor
Biosciences Graduate Program Association
Publications
  1. Wildenberg GA, Rosen MR, Lundell J, Paukner D, Freedman DJ, Kasthuri N. Primate neuronal connections are sparse in cortex as compared to mouse. Cell Rep. 2021 Sep 14; 36(11):109709. View in: PubMed

  2. Trinkle S, Foxley S, Wildenberg G, Kasthuri N, La Rivière P. The role of spatial embedding in mouse brain networks constructed from diffusion tractography and tracer injections. Neuroimage. 2021 Sep 11; 244:118576. View in: PubMed

  3. Sampathkumar V, Miller-Hansen A, Sherman SM, Kasthuri N. Integration of signals from different cortical areas in higher order thalamic neurons. Proc Natl Acad Sci U S A. 2021 Jul 27; 118(30). View in: PubMed

  4. Foxley S, Sampathkumar V, De Andrade V, Trinkle S, Sorokina A, Norwood K, La Riviere P, Kasthuri N. Multi-modal imaging of a single mouse brain over five orders of magnitude of resolution. Neuroimage. 2021 09; 238:118250. View in: PubMed

  5. Ofer N, Berger DR, Kasthuri N, Lichtman JW, Yuste R. Ultrastructural analysis of dendritic spine necks reveals a continuum of spine morphologies. Dev Neurobiol. 2021 Jul; 81(5):746-757. View in: PubMed

  6. Trinkle S, Foxley S, Kasthuri N, La Rivière P. Synchrotron X-ray micro-CT as a validation dataset for diffusion MRI in whole mouse brain. Magn Reson Med. 2021 08; 86(2):1067-1076. View in: PubMed

  7. Sampathkumar V, Miller-Hansen A, Murray Sherman S, Kasthuri N. An ultrastructural connectomic analysis of a higher-order thalamocortical circuit in the mouse. Eur J Neurosci. 2021 02; 53(3):750-762. View in: PubMed

  8. Prasad JA, Balwani AH, Johnson EC, Miano JD, Sampathkumar V, De Andrade V, Fezzaa K, Du M, Vescovi R, Jacobsen C, Kording KP, Gürsoy D, Gray Roncal W, Kasthuri N, Dyer EL. A three-dimensional thalamocortical dataset for characterizing brain heterogeneity. Sci Data. 2020 10 20; 7(1):358. View in: PubMed

  9. Abbott LF, Bock DD, Callaway EM, Denk W, Dulac C, Fairhall AL, Fiete I, Harris KM, Helmstaedter M, Jain V, Kasthuri N, LeCun Y, Lichtman JW, Littlewood PB, Luo L, Maunsell JHR, Reid RC, Rosen BR, Rubin GM, Sejnowski TJ, Seung HS, Svoboda K, Tank DW, Tsao D, Van Essen DC. The Mind of a Mouse. Cell. 2020 09 17; 182(6):1372-1376. View in: PubMed

  10. Foxley S, Wildenberg G, Sampathkumar V, Karczmar GS, Brugarolas P, Kasthuri N. Sensitivity to myelin using model-free analysis of the water resonance line-shape in postmortem mouse brain. Magn Reson Med. 2021 02; 85(2):667-677. View in: PubMed

  11. Dai W, Nadadur RD, Brennan JA, Smith HL, Shen KM, Gadek M, Laforest B, Wang M, Gemel J, Li Y, Zhang J, Ziman BD, Yan J, Ai X, Beyer EC, Lakata EG, Kasthuri N, Efimov IR, Broman MT, Moskowitz IP, Shen L, Weber CR. ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction. Circ Res. 2020 07 03; 127(2):e28-e43. View in: PubMed

  12. De Rossi P, Nomura T, Andrew RJ, Masse NY, Sampathkumar V, Musial TF, Sudwarts A, Recupero AJ, Le Metayer T, Hansen MT, Shim HN, Krause SV, Freedman DJ, Bindokas VP, Kasthuri N, Nicholson DA, Contractor A, Thinakaran G. Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation. Cell Rep. 2020 03 10; 30(10):3520-3535.e7. View in: PubMed

  13. Shahbazi A, Kinnison J, Vescovi R, Du M, Hill R, Joesch M, Takeno M, Zeng H, da Costa NM, Grutzendler J, Kasthuri N, Scheirer WJ. Publisher Correction: Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes. Sci Rep. 2018 Nov 29; 8(1):17585. View in: PubMed

  14. Shahbazi A, Kinnison J, Vescovi R, Du M, Hill R, Joesch M, Takeno M, Zeng H, da Costa NM, Grutzendler J, Kasthuri N, Scheirer WJ. Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes. Sci Rep. 2018 09 24; 8(1):14247. View in: PubMed

  15. Yang X, De Andrade V, Scullin W, Dyer EL, Kasthuri N, De Carlo F, Gürsoy D. Low-dose x-ray tomography through a deep convolutional neural network. Sci Rep. 2018 02 07; 8(1):2575. View in: PubMed

  16. Dyer EL, Gray Roncal W, Prasad JA, Fernandes HL, Gürsoy D, De Andrade V, Fezzaa K, Xiao X, Vogelstein JT, Jacobsen C, Körding KP, Kasthuri N. Quantifying Mesoscale Neuroanatomy Using X-Ray Microtomography. eNeuro. 2017 Sep-Oct; 4(5). View in: PubMed

  17. Ocola LE, Sampathkumar V, Kasthuri N, Winarski RP. Contrast enhancement of biological nanoporous materials with zinc oxide infiltration for electron and X-ray nanoscale microscopy. Sci Rep. 2017 07 19; 7(1):5879. View in: PubMed

  18. Bouchard KE, Aimone JB, Chun M, Dean T, Denker M, Diesmann M, Donofrio DD, Frank LM, Kasthuri N, Koch C, Ruebel O, Simon HD, Sommer FT. High-Performance Computing in Neuroscience for Data-Driven Discovery, Integration, and Dissemination. Neuron. 2016 Nov 02; 92(3):628-631. View in: PubMed

  19. Ai-Awami AK, Beyer J, Haehn D, Kasthuri N, Lichtman JW, Pfister H, Hadwiger M. NeuroBlocks--Visual Tracking of Segmentation and Proofreading for Large Connectomics Projects. IEEE Trans Vis Comput Graph. 2016 Jan; 22(1):738-46. View in: PubMed

  20. Haehn D, Knowles-Barley S, Roberts M, Beyer J, Kasthuri N, Lichtman JW, Pfister H. Design and Evaluation of Interactive Proofreading Tools for Connectomics. IEEE Trans Vis Comput Graph. 2014 Dec; 20(12):2466-75. View in: PubMed

  21. Al-Awami AK, Beyer J, Strobelt H, Kasthuri N, Lichtman JW, Pfister H, Hadwiger M. NeuroLines: A Subway Map Metaphor for Visualizing Nanoscale Neuronal Connectivity. IEEE Trans Vis Comput Graph. 2014 Dec; 20(12):2369-78. View in: PubMed

  22. Kasthuri N, Hayworth KJ, Berger DR, Schalek RL, Conchello JA, Knowles-Barley S, Lee D, Vázquez-Reina A, Kaynig V, Jones TR, Roberts M, Morgan JL, Tapia JC, Seung HS, Roncal WG, Vogelstein JT, Burns R, Sussman DL, Priebe CE, Pfister H, Lichtman JW. Saturated Reconstruction of a Volume of Neocortex. Cell. 2015 Jul 30; 162(3):648-61. View in: PubMed

  23. Kaynig V, Vazquez-Reina A, Knowles-Barley S, Roberts M, Jones TR, Kasthuri N, Miller E, Lichtman J, Pfister H. Large-scale automatic reconstruction of neuronal processes from electron microscopy images. Med Image Anal. 2015 May; 22(1):77-88. View in: PubMed

  24. Beyer J, Hadwiger M, Al-Awami A, Jeong WK, Kasthuri N, Lichtman JW, Pfister H. Exploring the connectome: petascale volume visualization of microscopy data streams. IEEE Comput Graph Appl. 2013 Jul-Aug; 33(4):50-61. View in: PubMed

  25. Tomassy GS, Berger DR, Chen HH, Kasthuri N, Hayworth KJ, Vercelli A, Seung HS, Lichtman JW, Arlotta P. Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex. Science. 2014 Apr 18; 344(6181):319-24. View in: PubMed

  26. Burns R, Roncal WG, Kleissas D, Lillaney K, Manavalan P, Perlman E, Berger DR, Bock DD, Chung K, Grosenick L, Kasthuri N, Weiler NC, Deisseroth K, Kazhdan M, Lichtman J, Reid RC, Smith SJ, Szalay AS, Vogelstein JT, Vogelstein RJ. The Open Connectome Project Data Cluster: Scalable Analysis and Vision for High-Throughput Neuroscience. Sci Stat Database Manag. 2013. View in: PubMed

  27. Beyer J, Al-Awami A, Kasthuri N, Lichtman JW, Pfister H, Hadwiger M. ConnectomeExplorer: query-guided visual analysis of large volumetric neuroscience data. IEEE Trans Vis Comput Graph. 2013 Dec; 19(12):2868-77. View in: PubMed

  28. Terasaki M, Shemesh T, Kasthuri N, Klemm RW, Schalek R, Hayworth KJ, Hand AR, Yankova M, Huber G, Lichtman JW, Rapoport TA, Kozlov MM. Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs. Cell. 2013 Jul 18; 154(2):285-96. View in: PubMed

  29. Glenn DR, Zhang H, Kasthuri N, Schalek R, Lo PK, Trifonov AS, Park H, Lichtman JW, Walsworth RL. Correlative light and electron microscopy using cathodoluminescence from nanoparticles with distinguishable colours. Sci Rep. 2012; 2:865. View in: PubMed

  30. Tapia JC, Wylie JD, Kasthuri N, Hayworth KJ, Schalek R, Berger DR, Guatimosim C, Seung HS, Lichtman JW. Pervasive synaptic branch removal in the mammalian neuromuscular system at birth. Neuron. 2012 Jun 07; 74(5):816-29. View in: PubMed

  31. Tapia JC, Kasthuri N, Hayworth KJ, Schalek R, Lichtman JW, Smith SJ, Buchanan J. High-contrast en bloc staining of neuronal tissue for field emission scanning electron microscopy. Nat Protoc. 2012 Jan 12; 7(2):193-206. View in: PubMed

  32. Fox MA, Tapia JC, Kasthuri N, Lichtman JW. Delayed synapse elimination in mouse levator palpebrae superioris muscle. J Comp Neurol. 2011 Oct 15; 519(15):2907-21. View in: PubMed

  33. Kasthuri N, Lichtman JW. Neurocartography. Neuropsychopharmacology. 2010 Jan; 35(1):342-3. View in: PubMed

  34. Kasthuri N, Lichtman JW. The rise of the 'projectome'. Nat Methods. 2007 Apr; 4(4):307-8. View in: PubMed

  35. Kasthuri N, Lichtman JW. Structural dynamics of synapses in living animals. Curr Opin Neurobiol. 2004 Feb; 14(1):105-11. View in: PubMed

  36. Kasthuri N, Lichtman JW. The role of neuronal identity in synaptic competition. Nature. 2003 Jul 24; 424(6947):426-30. View in: PubMed

  37. Grutzendler J, Kasthuri N, Gan WB. Long-term dendritic spine stability in the adult cortex. Nature. 2002 Dec 19-26; 420(6917):812-6. View in: PubMed

  38. Kettunen P, Demas J, Lohmann C, Kasthuri N, Gong Y, Wong RO, Gan WB. Imaging calcium dynamics in the nervous system by means of ballistic delivery of indicators. J Neurosci Methods. 2002 Sep 15; 119(1):37-43. View in: PubMed

  39. Pike FG, Goddard RS, Suckling JM, Ganter P, Kasthuri N, Paulsen O. Distinct frequency preferences of different types of rat hippocampal neurones in response to oscillatory input currents. J Physiol. 2000 Nov 15; 529 Pt 1:205-13. View in: PubMed