We investigate the molecular machinery underlying synaptic plasticity and information processing in the brain. We are especially interested in synaptic mechanisms supporting reinforcement learning and motor control. Our main approaches include mouse genetics, fly genetics, optogenetics, animal learning paradigms, electrophysiology, molecular biology and RNA-seq.
YTHDF1 mediates translational control by m6A mRNA methylation in adaptation to environmental challenges.
YTHDF1 mediates translational control by m6A mRNA methylation in adaptation to environmental challenges. bioRxiv. 2024 Aug 09.
PMID: 39149343
m6A RNA methylation regulates mitochondrial function.
m6A RNA methylation regulates mitochondrial function. Hum Mol Genet. 2024 05 18; 33(11):969-980.
PMID: 38483349
FMRP phosphorylation modulates neuronal translation through YTHDF1.
FMRP phosphorylation modulates neuronal translation through YTHDF1. Mol Cell. 2023 Dec 07; 83(23):4304-4317.e8.
PMID: 37949069
Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed by In Vitro Cellular Studies and In Vivo PET Imaging.
Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed by In Vitro Cellular Studies and In Vivo PET Imaging. J Neurosci. 2023 01 04; 43(1):2-13.
PMID: 36028313
Drosophila carrying epilepsy-associated variants in the vitamin B6 metabolism gene PNPO display allele- and diet-dependent phenotypes.
Drosophila carrying epilepsy-associated variants in the vitamin B6 metabolism gene PNPO display allele- and diet-dependent phenotypes. Proc Natl Acad Sci U S A. 2022 03 01; 119(9).
PMID: 35217610
RNA-binding protein syncrip regulates starvation-induced hyperactivity in adult Drosophila.
RNA-binding protein syncrip regulates starvation-induced hyperactivity in adult Drosophila. PLoS Genet. 2021 02; 17(2):e1009396.
PMID: 33617535
Pyridox (am) ine 5'-phosphate oxidase deficiency induces seizures in Drosophila melanogaster.
Chi W, Iyengar ASR, Albersen M, Bosma M, Verhoeven-Duif NM, Wu CF, Zhuang X. Pyridox (am) ine 5'-phosphate oxidase deficiency induces seizures in Drosophila melanogaster. Hum Mol Genet. 2019 09 15; 28(18):3126-3136.
PMID: 31261385
Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning.
Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning. Neuron. 2018 07 25; 99(2):283-292.e5.
PMID: 30056831
Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.
Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, Krainc D. Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease. Science. 2017 09 22; 357(6357):1255-1261.
PMID: 28882997
Chronic Nicotine Mitigates Aberrant Inhibitory Motor Learning Induced by Motor Experience under Dopamine Deficiency.
Chronic Nicotine Mitigates Aberrant Inhibitory Motor Learning Induced by Motor Experience under Dopamine Deficiency. J Neurosci. 2016 05 11; 36(19):5228-40.
PMID: 27170121